非hla基因与多发性硬化症

J. Borjac, Alaa Matar, Maxime Merheb, C. Vazhappilly, Rachel Matar
{"title":"非hla基因与多发性硬化症","authors":"J. Borjac, Alaa Matar, Maxime Merheb, C. Vazhappilly, Rachel Matar","doi":"10.2174/18740707-v17-e230316-2022-25","DOIUrl":null,"url":null,"abstract":"Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Identification of genetic variants that pose risks to MS is of high interest since they contribute largely to disease pathogenesis. A rich body of literature associated these risks with variants of HLA genes located mostly on the short arm of chromosome 6 (6p21). These genetic variations may result in alteration in protein function and are associated, therefore, with disease phenotype and therapy outcome. Although the HLA region has been routinely known to have the strongest correlation with MS, other genes found within and outside HLA locus are considered risk factors for MS. The objective of this review is to shed light on the non-HLA genes implicated with multiple sclerosis. Due to the interplay between the polygenetic and environmental factors, along with their differential contribution and genetic heterogeneity among populations, it is extremely challenging to determine the contribution of the non-HLA genes to the outcome and onset of MS disease. We conclude that a better assemblage of genetic factors involved in MS can have a critical impact on the establishment of a genetic map of MS that allows proper investigation at the expression and functional levels.","PeriodicalId":296126,"journal":{"name":"The Open Biotechnology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-HLA Genes and Multiple Sclerosis\",\"authors\":\"J. Borjac, Alaa Matar, Maxime Merheb, C. Vazhappilly, Rachel Matar\",\"doi\":\"10.2174/18740707-v17-e230316-2022-25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Identification of genetic variants that pose risks to MS is of high interest since they contribute largely to disease pathogenesis. A rich body of literature associated these risks with variants of HLA genes located mostly on the short arm of chromosome 6 (6p21). These genetic variations may result in alteration in protein function and are associated, therefore, with disease phenotype and therapy outcome. Although the HLA region has been routinely known to have the strongest correlation with MS, other genes found within and outside HLA locus are considered risk factors for MS. The objective of this review is to shed light on the non-HLA genes implicated with multiple sclerosis. Due to the interplay between the polygenetic and environmental factors, along with their differential contribution and genetic heterogeneity among populations, it is extremely challenging to determine the contribution of the non-HLA genes to the outcome and onset of MS disease. We conclude that a better assemblage of genetic factors involved in MS can have a critical impact on the establishment of a genetic map of MS that allows proper investigation at the expression and functional levels.\",\"PeriodicalId\":296126,\"journal\":{\"name\":\"The Open Biotechnology Journal\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Biotechnology Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/18740707-v17-e230316-2022-25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Biotechnology Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/18740707-v17-e230316-2022-25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

多发性硬化症(MS)是一种中枢神经系统自身免疫性脱髓鞘疾病。鉴定对多发性硬化症构成风险的遗传变异是高度感兴趣的,因为它们在很大程度上有助于疾病的发病机制。大量文献将这些风险与主要位于6号染色体短臂(6p21)的HLA基因变异联系起来。这些遗传变异可能导致蛋白质功能的改变,因此与疾病表型和治疗结果相关。尽管人们通常认为HLA区域与多发性硬化症的相关性最强,但在HLA位点内外发现的其他基因被认为是多发性硬化症的危险因素。本综述的目的是阐明与多发性硬化症有关的非HLA基因。由于多遗传和环境因素之间的相互作用,以及它们在人群中的差异贡献和遗传异质性,确定非hla基因对MS疾病的结局和发病的贡献是极具挑战性的。我们得出的结论是,更好地组合与多发性硬化症有关的遗传因素可以对建立多发性硬化症的遗传图谱产生关键影响,从而可以在表达和功能水平上进行适当的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Non-HLA Genes and Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. Identification of genetic variants that pose risks to MS is of high interest since they contribute largely to disease pathogenesis. A rich body of literature associated these risks with variants of HLA genes located mostly on the short arm of chromosome 6 (6p21). These genetic variations may result in alteration in protein function and are associated, therefore, with disease phenotype and therapy outcome. Although the HLA region has been routinely known to have the strongest correlation with MS, other genes found within and outside HLA locus are considered risk factors for MS. The objective of this review is to shed light on the non-HLA genes implicated with multiple sclerosis. Due to the interplay between the polygenetic and environmental factors, along with their differential contribution and genetic heterogeneity among populations, it is extremely challenging to determine the contribution of the non-HLA genes to the outcome and onset of MS disease. We conclude that a better assemblage of genetic factors involved in MS can have a critical impact on the establishment of a genetic map of MS that allows proper investigation at the expression and functional levels.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Terminalia Arjuna (Roxb.) Wight & amp; Arn: Unveiling its Potential as a Mosquito Control Agent through Biosynthesized Nanomaterials and Computational Analysis against Aedes Aegypti and Aedes Albopictus Navigating the Nanoscale: Unraveling the Complexities of Metallic Nanoparticle Biosynthesis for Biomedical Breakthroughs and Addressing Toxicity Concerns Isolation and Characterization of Polyethylene and Polyethylene Terephthalate-degrading Bacteria from Jakarta Bay, Indonesia Isolation and Characterization of Polyethylene and Polyethylene Terephthalate-degrading Bacteria from Jakarta Bay, Indonesia Rapid In Vitro Regeneration and Genetic Fidelity Assessment of Regenerated Plants in Ayapana Triplinervis (Vahl) R.M. King & H. Robinson: An Ethnomedicinal and Ornamental Herb
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1