hiv相关感觉神经病变

F. Octaviana, A. Safri, D. Imran, P. Price
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引用次数: 1

摘要

随着艾滋病毒治疗的进步使患者的寿命延长,进一步的合并症变得明显。这包括可能影响患者生活质量的感觉神经病变(HIV-SN)。在这里,我们回顾了在接受抗逆转录病毒治疗的患者中影响HIV-SN的因素,这些因素促进了这种情况的发生,并且在现代,这些治疗已经被撤销。这使HIV-SN的发病率减少了一半,但这种情况在许多患者的生活中仍然很重要。影响HIV-SN发病机制的遗传多态性已经指出了可能的机制,但需要对皮肤活检和动物模型进行研究来确认编码蛋白的作用。
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HIV-Associated Sensory Neuropathy
As advances in the treatment of HIV are now allowing patients a longer life span, further comorbidities become apparent. This includes sensory neuropathy (HIV-SN) which can affect a patient’s quality of life. Here, we review factors influencing HIV-SN in patients receiving antiretroviral therapy that promotes this condition and in the modern era when these therapies have been withdrawn. This has halved the incidence of HIV-SN, but the condition remains significant in the lives of many sufferers. Genetic polymorphisms that influence pathogenesis of HIV-SN have indicated likely mechanisms, but studies of skin biopsies and animal models are needed to confirm the roles of the encoded proteins.
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