[血小板活化因子结构类似物的抗炎活性]。

Farmakologiia i toksikologiia Pub Date : 1991-07-01

A G Melikiants, V I Kulikov, E E Koloskova, T I Kuznetsova, A A Dergousov, L Iu Lipatkina

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引用次数: 0

摘要

研究了血小板活化因子(PAF)的新结构类似物的促炎活性和抗炎活性。发现三种PAF类似物以剂量依赖的方式抑制PAF诱导的大鼠足跖水肿。其中一种PAF类似物对PAF-或卡拉胶诱导的炎症的抗炎活性与地塞米松相当或在一定程度上超过地塞米松。

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[The anti-inflammatory activity of structural analogs of the platelet-activating factor].

The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.

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Farmakologiia i toksikologiia

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