通过两种不同输液器时硝酸甘油的损失。

Acta pharmaceutica Nordica Pub Date : 1991-01-01
H C Hansen, A Spillum
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引用次数: 0

摘要

研究了通过聚氯乙烯(PVC)或聚乙烯(PE)输液器时硝酸甘油(GTN)的损失。GTN浓度对聚氯乙烯组中GTN的损失没有影响。该研究证实了文献中的报道,即GTN的最大损失发生在最慢的输注速度下。有趣的是,当与输液器容量相当的体积通过输液器时,GTN浓度最低。当我们模拟挪威和瑞典卫生当局推荐的程序时,我们观察到在前30分钟通过PVC输液期间损失高达70%,在接下来的7小时内下降到30%。PE组在8小时内的损失不超过15%。
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Loss of nitroglycerin during passage through two different infusion sets.

The loss of nitroglycerin (GTN) during passage through a polyvinyl chloride (PVC) or polyethylene (PE) infusion set was investigated. The GTN concentration had no influence on the GTN loss in the PVC set. The study confirmed reports in the literature that the greatest loss of GTN occurs at the slowest rate of infusion. Interestingly, the lowest concentration of GTN is seen when the volume equivalent to the capacity of the infusion set has passed through the set. When we simulated the procedure recommended by the health authorities in Norway and Sweden, we observed a loss of up to 70% during infusion through the PVC set in the first 30 minutes, which decreased to 30% over the next seven hours. The loss from the PE set did not exceed 15% over eight hours.

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