[评估生物活性物质前庭保护作用的新方法的充分性]。

Farmakologiia i toksikologiia Pub Date : 1991-09-01
N N Karkishchenko, N A Dimitriadi
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引用次数: 0

摘要

研究了几种神经精神药物在复合加速作用下对白化雄性大鼠疼痛敏感性的影响。研究发现,服用具有抗晕动病活性的药物——东莨菪碱、苯那明、苯乃可阻止阿片类药物产生镇痛作用,而使用抑制前庭植物干扰的低效和无效药物——地西泮、麻黄碱、氟哌啶醇未能发挥这种作用。
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[The adequacy of a new method for assessing the vestibular protective effect of biologically active substances].

The effects of some neuropsychotropic agents on changes in pain sensitivity in albino male rats under the action of complex accelerations were investigated. It was found that administration of drugs with the antimotion-sickness activity--scopolamine, phenamine, phenibut prevented the development of analgesia with the opiate component, the use of low-effective and non-effective with respect to suppression of vestibulo-vegetative disturbances agents--diazepam, ephedrine, haloperidol failed to exert such an effect.

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