desmod躯干和四肢手术复发的预测因素

А. В. Ядрина, В. Ю. Карпенко, Ольга Вячеславовна Новикова, Н. М. Бычкова, В. А. Державин, А. В. Бухаров
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引用次数: 1

摘要

研究目的:重建整形手术治疗硬纤维瘤(DF)的效果评价及复发可能的预后因素的确定。患者和方法。分析40例腹外局部硬纤维瘤的手术治疗结果。在45%的患者中,肿瘤位于肩带和上肢的软组织,35%的患者位于躯干,20%的患者位于下肢软组织,7%的患者位于颈部。肿瘤大小为2 ~ 20 cm,中位数为8±4.38 cm。22例(55%)患者对新诊断的DF进行了手术治疗,18例(45%)患者对复发肿瘤进行了手术治疗。结果。根据计划的组织学研究,24/40(63%)患者建立了阴性切除边界。其余16例(37%)获得阳性切缘:14例为R1, 2例为R2。14例R1/R2切除患者推荐辅助治疗。治疗后随访时间为6 ~ 107个月,中位为16.5个月。随访期间,14例(35%)患者被诊断为复发。目前没有死亡报告。结论。腹外定位DF的手术治疗伴有足够高的复发频率。根据研究结果,肿瘤在肩带和上肢软组织的位置是复发发展的不利因素。
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ПРОГНОСТИЧЕСКИЕ ФАКТОРЫ РЕЦИДИВОВ ПРИ ХИРУРГИЧЕСКОМ ЛЕЧЕНИИ ДЕСМОИДНЫХ ФИБРОМ ТУЛОВИЩА И КОНЕЧНОСТЕЙ
Purpose of the study . Evaluation of the results of surgical treatment of desmoid fibroids (DF) using reconstructive plastic surgery and determination of possible prognostic factors of relapses. Patients and methods . The results of surgical treatment of 40 patients with desmoid fibroids of extra abdominal local­ization were analyzed. In 45% of patients, the tumor was located in soft tissues of the shoulder girdle and upper limb, in 35% — on the trunk, in 20% — in soft tissues of the lower limb and in 7% of patients on the neck. The tumor size varied from 2 to 20 cm, the median was 8 ± 4.38 cm. Surgical treatment for newly diagnosed DF was performed in 22 (55%) patients, and for recurrent tumors — in 18 (45%) patients. Results . According to the planned histological study, negative resection boundaries were established in 24/40 patients (63%). In the remaining 16 cases (37%) positive resection margins were obtained: R1 in 14 patients and R2 in 2 patients. Adjuvant treatment is recommended for 14 patients with resection R1/R2. The duration of follow — up after treatment ranged from 6 to 107 months, median‑16.5 months. During follow-up, relapses were diagnosed in 14 patients (35%). No deaths have been reported. Conclusion . Surgical treatment of DF of extraabdominal localization is accompanied by a sufficiently high frequency of relapses. According to the results of the study, an unfavorable factor in the development of relapses is the location of the tumor in soft tissues of the shoulder girdle and upper limb.
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