评价不同程度肺动脉高压犬RPAD指数的临床价值

Dushyant M. Nijhawan, R. Chawla, M. Saxena, S. Dixit, Vidushi Sharma
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摘要

背景:测量肺动脉压的金标准是右心导管。本研究旨在评估不同程度肺动脉高压犬RPAD指数的临床价值。对象与方法:本研究选取40只犬。根据TRPG值(75 mmHg)将狗分为四组。在所有的狗中,都记录了与PH相关的体征。结果:40只犬中,公犬25只,母犬15只。常见临床表现为咳嗽24例,呼吸急促11例,虚弱18例,呼吸困难27例,晕厥5例,咯血34例。平均心率I组为130.2,II组为121.4,III组为141.3,IV组为147.5。临床评分I组为2.5分,II组为3.7分,III组为5.11分,IV组为5.8分。放射学平均评分分别为:I组1.3分、II组2.4分、III组2.9分、IV组3.8分,分数缩短分别为:I组46.5%、II组50.3%、III组55.4%、IV组53.2%,差异有统计学意义(P< 0.05)。结论:不同肺动脉压下犬的平均心率、临床评分、放射学评分和缩短时间均有显著差异。
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To Assess the Clinical Value of the RPAD Index in Dogs with Varying Degrees of Pulmonary Hypertension
Background: The gold standard for pulmonary artery pressure measurement is right heart catheterization. The present study was conducted to assess the clinical value of the RPAD index in dogs with varying degrees of pulmonary hypertension. Subjects and Methods: The present study was conducted on 40 dogs. Dogs were divided in four groups according to the TRPG value (<36 mmHg, 36–50 mmHg, 51–75 mmHg, or >75 mmHg). In all dogs, presence of signs commonly associated with PH was recorded. Results: Out of 40 dogs, male dogs were 25 and female dogs were 15. Common clinical features were coughing in 24, tachypnea in 11, weakness in 18, dyspnea in 27, syncope in 5 and hemoptysis in 34. The mean heart rate in group I was 130.2, in group II was 121.4, in group III was 141.3 and in group IV was 147.5. Clinical score in group I was 2.5, in group II was 3.7, in group III was 5.11 and in group IV was 5.8. Mean radiology score was 1.3 in group I, 2.4 in group II, 2.9 in group III and 3.8 in group IV. Fractional shortening was 46.5% in group I, 50.3% in group II, 55.4% in group III and 53.2% in group IV. The difference was significant (P< 0.05). Conclusion: Authors found significant difference in mean heart rate, clinical score, radiology score and fractional shortening in dogs with different pulmonary pressure.
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