Central Sensitization: The Unrecognized Expression of Autonomic Dysregulation

Central sensitization is a condition that is usually associated with chronic pain, and refers to a heightened level of spinal cord neuron excitability compared to normal activation levels. In addition to this hyperexcitability resulting in a disproportionately elevated pain response, the accompanying sensory receptor field expansion can also increase responsiveness to non- painful stimulation. Recent studies have examined the role that autonomic nervous system dysfunction plays in the development of central sensitization (1). These findings underscore the potentiality that mediating autonomic output presents as an effective means of moderating central sensitization.