{"title":"氨基酸包被UHMW-PE植入物对皮下成纤维细胞迁移的影响","authors":"K. Butler, H. Benghuzzi, M. Tucci, A. Puckett","doi":"10.1109/SBEC.2016.10","DOIUrl":null,"url":null,"abstract":"The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subcutaneous Fibroblast Migration is Altered by Amino Acid Coated UHMW-PE Implants\",\"authors\":\"K. Butler, H. Benghuzzi, M. Tucci, A. Puckett\",\"doi\":\"10.1109/SBEC.2016.10\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.\",\"PeriodicalId\":196856,\"journal\":{\"name\":\"2016 32nd Southern Biomedical Engineering Conference (SBEC)\",\"volume\":\"23 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2016 32nd Southern Biomedical Engineering Conference (SBEC)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/SBEC.2016.10\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/SBEC.2016.10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Subcutaneous Fibroblast Migration is Altered by Amino Acid Coated UHMW-PE Implants
The purpose of this investigation was to determine fibroblast behavior after implantation of ultra-high molecular weight polyethylene (UHMW-PE) rinsed with saline (control) or coated with poly-L-lysine (PLL), arginine-glycine-aspartic acid (RGD), or arginine-glycine-glutamic acid (RGE) into 16 adult male rats subcutaneously. At 90 days post-implantation, fibroblast counts were highest in the saline rinsed group (34±2 cells/HPF) and significantly reduced in RGD (19±10), RGE (2±3), and PLL (0) treated groups. These findings indicate fibroblast migration in surrounding fibrous tissue can be strongly influenced using various amino acid combination coatings in subcutaneous applications.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
