3D point distribution models of the cortical sulci

In this paper we present the first steps in the development of a statistical shape model, specifically a point distribution model (PDM), of the cortical surface of the brain. This will ultimately be used to locate, label, and describe the cortex, for visualisation, diagnosis, and quantification. In order to produce the model it was necessary to find and label the sulcal fissures on a series of MR images. Due to the complexity of the surface, an automated method was developed to facilitate development of a full surface model. Automating the marking process introduced the problem of identifying correspondences between examples, the knowledge of which is essential to the development of a PDM. Various methods were investigated to solve this problem including simple point matching and more complex curve matching. Each is outlined and discussed. The models obtained so far provide interesting insights into the shape and cortical pattern variations over a group of normal subjects.