纳米药物在心血管疾病治疗中的应用

Qiang Xie, Hongmei Yang, Wenjie Shi
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摘要

心血管疾病仍然是一种高发病率和高死亡率的疾病。虽然先进的技术不断增加我们对心血管疾病的了解,但其诊断和治疗仍然存在局限性。纳米技术作为一种新兴的跨学科方法,已显示出巨大的临床应用潜力。纳米材料具有独特的物理和化学性质,有助于提高生物传感器技术和分子成像技术在心血管疾病诊断中的灵敏度和特异性。本文首先综述了纳米材料的通用性、生物分子工程的理化可调性、纳米材料在心脑血管疾病中的设计策略、纳米材料在常见心血管疾病诊断和治疗中的应用,以及使用纳米材料可显著提高诊断敏感性、特异性和治疗效果。随后,文章对各种纳米材料进行了总结。最后,文章展示了纳米材料的抗氧化/抗炎和光电/光热特性直接应用于心血管疾病治疗的潜力。
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Application of nanodrugs in the treatment of cardiovascular diseases
Cardiovascular disease is still a disease with high incidence rate and mortality. Although advanced technology continues to increase our understanding of cardiovascular disease, its diagnosis and treatment still have limitations. As an emerging interdisciplinary method, nanotechnology has shown enormous clinical application potential. Nanomaterials have unique physical and chemical properties, which help to improve the sensitivity and specificity of biosensor technology and molecular imaging technology in the diagnosis of cardiovascular diseases. This paper first summarizes the versatility of nanomaterials, the physicochemical adjustability of biomolecular engineering, the design strategy of nanoparticles in cardio cerebral Vascular disease, the application of nanomaterials in the diagnosis and treatment of common cardiovascular diseases, and the use of nanomaterials can significantly improve the diagnostic sensitivity, specificity and therapeutic effect. Subsequently, the article summarized various nanomaterials. Finally, the article demonstrated the potential of the antioxidant/anti-inflammatory and photoelectric/photothermal properties of nanomaterials to be directly applied to the treatment of cardiovascular diseases.
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