多光子显微镜下肝纤维化的光学活检

Yuan Liu, Hsuan-Shu Lee, Hsiao-Ching Chen, L. Chiou, Guan-Tarn Huang, Wen Lo, C. Dong
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引用次数: 2

摘要

在这项工作中,我们应用多光子显微镜诊断毒素(CCl/sub - 4/)诱导的小鼠肝纤维化。我们发现,多光子诱导光谱特征可用于识别星状细胞增殖和坏死部位。我们的研究表明,多光子成像可能成为体内肝纤维化的有效诊断工具。
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Optical biopsy of liver fibrosis using multiphoton microscopy
In this work, we apply multiphoton microscopy in diagnosing toxin (CCl/sub 4/) induced liver fibrosis in mice. We found that multiphoton induced spectroscopic signatures may be used to identify stellate cell proliferation and necrotic sites. Our study suggests that multiphoton imaging may be developed into an effective diagnosis tool for liver fibrosis in vivo.
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