This paper describes the feature of train driver focusing on brain activity measured by using the newly developed train simulator and functional near-infrared spectroscopy (fNIRS). The developed train simulator can simulate the real train operation with designed task condition for measuring brain function of train driver. Blood flow measurement is carried out manual and automatic train operation. It is pointed out that the difference between manual operation and automatic operation can be seen in the blood flow of frontal lobe.
{"title":"Measurement of train driver's brain activity by functional near-infrared spectroscopy (fNIRS)","authors":"T. Kojima, H. Tsunashima, T. Shiozawa, H. Takada","doi":"10.2495/CR060251","DOIUrl":"https://doi.org/10.2495/CR060251","url":null,"abstract":"This paper describes the feature of train driver focusing on brain activity measured by using the newly developed train simulator and functional near-infrared spectroscopy (fNIRS). The developed train simulator can simulate the real train operation with designed task condition for measuring brain function of train driver. Blood flow measurement is carried out manual and automatic train operation. It is pointed out that the difference between manual operation and automatic operation can be seen in the blood flow of frontal lobe.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2006-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132541291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412366
Y. Matsuura
A beam delivery system involving a flexible hollow optical-fiber is introduced. For uses in medicine, the output end of the fiber is sealed with a silica-glass cap. A result of laser lithotripsy experiment is reported.
{"title":"Hollow fibers for medical applications","authors":"Y. Matsuura","doi":"10.1109/APBP.2004.1412366","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412366","url":null,"abstract":"A beam delivery system involving a flexible hollow optical-fiber is introduced. For uses in medicine, the output end of the fiber is sealed with a silica-glass cap. A result of laser lithotripsy experiment is reported.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122174012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412341
S. Teng, Hsiao-Ching Chen, L. Chiou, Wen Lo, Hsuan-Shu Lee, C. Dong
Multiphoton microscopy is a nonlinear excitation imaging technique useful in probing structural and dynamic phenomena in biological systems. In this work, the advantages of multiphoton microscopy is explored to follow the physiological changes to tissue engineered cartilage using human mesenchymal bone marrow stem cells cultured in polyglycolic acid (PGA) scaffold. Multiphoton induced intrinsic luminescence signals from these specimens reveal the generation of extracellular matrix distorts the PGA scaffolds and show that multiphoton microscopy can be a useful technique in assessing the physiological states of tissue engineered constructs.
{"title":"Mechanisms of artificial cartilage generation in polyglycolic acid scaffold revealed by multiphoton microscopy","authors":"S. Teng, Hsiao-Ching Chen, L. Chiou, Wen Lo, Hsuan-Shu Lee, C. Dong","doi":"10.1109/APBP.2004.1412341","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412341","url":null,"abstract":"Multiphoton microscopy is a nonlinear excitation imaging technique useful in probing structural and dynamic phenomena in biological systems. In this work, the advantages of multiphoton microscopy is explored to follow the physiological changes to tissue engineered cartilage using human mesenchymal bone marrow stem cells cultured in polyglycolic acid (PGA) scaffold. Multiphoton induced intrinsic luminescence signals from these specimens reveal the generation of extracellular matrix distorts the PGA scaffolds and show that multiphoton microscopy can be a useful technique in assessing the physiological states of tissue engineered constructs.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116868561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412376
A. Oraevsky
Recent developments of laser optoacoustic imaging system, a new medical imaging modality utilizing endogenous contrast of blood enhanced with exogenous contrast of gold nanoparticles for real-time high-resolution high-sensitivity detection of cancer and monitoring of cancer therapy are reviewed.
{"title":"Detection, diagnostics and image-guided therapy of cancer using laser optoacoustic imaging system and gold nanoparticles","authors":"A. Oraevsky","doi":"10.1109/APBP.2004.1412376","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412376","url":null,"abstract":"Recent developments of laser optoacoustic imaging system, a new medical imaging modality utilizing endogenous contrast of blood enhanced with exogenous contrast of gold nanoparticles for real-time high-resolution high-sensitivity detection of cancer and monitoring of cancer therapy are reviewed.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121509317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412251
B. Lee, EunSeo Choi
All-fiber optical delay line suitable for the applications of optical coherence tomography has been implemented. The distributed reflection property of an optical fiber grating was utilized in achieving true time delay.
实现了适合光学相干层析成像应用的全光纤延迟线。利用光纤光栅的分布反射特性实现了真正的时延。
{"title":"Implementation of all-fiber optical delay line and applications for optical coherence tomography","authors":"B. Lee, EunSeo Choi","doi":"10.1109/APBP.2004.1412251","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412251","url":null,"abstract":"All-fiber optical delay line suitable for the applications of optical coherence tomography has been implemented. The distributed reflection property of an optical fiber grating was utilized in achieving true time delay.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121558970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412298
M. Ishihara, M. Sato, S. Sato, J. Mochida, M. Kikuchi
We proposed a measurement method for noninvasive functional characterization of cartilage for therapeutic validation. As relaxation times of laser-induced stress wave give the viscosity-elasticity ratio of samples, measurement of the relaxation times enables viscoelastic characterization.
{"title":"Importance of noninvasive functional measurement for therapeutic validation; Viscoelastic characterization by photoacoustic measurement","authors":"M. Ishihara, M. Sato, S. Sato, J. Mochida, M. Kikuchi","doi":"10.1109/APBP.2004.1412298","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412298","url":null,"abstract":"We proposed a measurement method for noninvasive functional characterization of cartilage for therapeutic validation. As relaxation times of laser-induced stress wave give the viscosity-elasticity ratio of samples, measurement of the relaxation times enables viscoelastic characterization.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127782597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412294
M. Jou
Using multiphoton laser scanning imaging microscopy the effects of subcellular localized PDT with the photosensitizer BPD-MA was studied in different cellular compartments including the mitochondria, the cytosol and the nucleus. Specifically, mitochondrial reactive oxygen species (mROS) and mitochondrial free calcium (mCa/sup 2+/) were measured simultaneously during PDT with BPD-MA induced mitochondrial dysfunction. Intriguingly, PDT with BPD-MA-induced mROS formation and mCa/sup 2+/ elevation as well as apoptotic death were found only when the mitochondrial compartment was illuminated. These data suggest that PDT with a mitochondria targeted photosensitizer can extensively enhance the efficacy of PDT via mROS and mCa/sup 2+/-mediated apoptotic mechanisms.
{"title":"Photosensitizer targeting: mitochondria-targeted photosensitizer enhances photodynamic effect and apoptosis","authors":"M. Jou","doi":"10.1109/APBP.2004.1412294","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412294","url":null,"abstract":"Using multiphoton laser scanning imaging microscopy the effects of subcellular localized PDT with the photosensitizer BPD-MA was studied in different cellular compartments including the mitochondria, the cytosol and the nucleus. Specifically, mitochondrial reactive oxygen species (mROS) and mitochondrial free calcium (mCa/sup 2+/) were measured simultaneously during PDT with BPD-MA induced mitochondrial dysfunction. Intriguingly, PDT with BPD-MA-induced mROS formation and mCa/sup 2+/ elevation as well as apoptotic death were found only when the mitochondrial compartment was illuminated. These data suggest that PDT with a mitochondria targeted photosensitizer can extensively enhance the efficacy of PDT via mROS and mCa/sup 2+/-mediated apoptotic mechanisms.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131121586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412252
Y. Watanabe, I. Wakaki, T. Niizuma, M. Sato
We demonstrated time-gated full-field OCT. We simultaneously measured two interference images that had a 90/spl deg/ phase difference using a CCD camera, and then obtained an en-face OCT image of an onion from two captured images.
{"title":"Time-gated full-field optical coherence tomography using optical Hilbert transformation","authors":"Y. Watanabe, I. Wakaki, T. Niizuma, M. Sato","doi":"10.1109/APBP.2004.1412252","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412252","url":null,"abstract":"We demonstrated time-gated full-field OCT. We simultaneously measured two interference images that had a 90/spl deg/ phase difference using a CCD camera, and then obtained an en-face OCT image of an onion from two captured images.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131403178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412259
H. Arimoto
A new method for measuring two-dimensional water content distribution on skin surface is presented. Water content of the stratum corneum affects the scattering properties over the skin surface. The difference of the scattering properties are visualized by introducing the polarization imaging technique. Polarization imaging enables us to divide reflected light into polarization maintained light and depolarized light which correspond to superficially reflected light and deeply penetrated light, respectively.
{"title":"Measurement of water content distribution on skin surface using polarization imaging","authors":"H. Arimoto","doi":"10.1109/APBP.2004.1412259","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412259","url":null,"abstract":"A new method for measuring two-dimensional water content distribution on skin surface is presented. Water content of the stratum corneum affects the scattering properties over the skin surface. The difference of the scattering properties are visualized by introducing the polarization imaging technique. Polarization imaging enables us to divide reflected light into polarization maintained light and depolarized light which correspond to superficially reflected light and deeply penetrated light, respectively.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125980181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2004-12-15DOI: 10.1109/APBP.2004.1412360
P. Lin
By utilizing the silicon oxide particle as the scattering point for surface plasmon resonance signal, we can make multiple measurement for bio-material on same chip.
利用氧化硅粒子作为表面等离子体共振信号的散射点，可以在同一芯片上对生物材料进行多次测量。
{"title":"Surface plasmon resonance signals scattered by nanoparticles","authors":"P. Lin","doi":"10.1109/APBP.2004.1412360","DOIUrl":"https://doi.org/10.1109/APBP.2004.1412360","url":null,"abstract":"By utilizing the silicon oxide particle as the scattering point for surface plasmon resonance signal, we can make multiple measurement for bio-material on same chip.","PeriodicalId":346624,"journal":{"name":"The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124816904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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