角蛋白和波形蛋白在乳腺癌组织中的表达与乳腺癌转移的关系

Y. Jegal, Jung-han Yoon, C. Park
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引用次数: 0

摘要

提示骨髓微转移的意义。然而,细胞角蛋白8、18和19表达的病例,总共75%或更多,显示出骨髓微转移的显著高风险。在这种情况下,vimentin表达的增加使得骨髓微转移的可能性更高。结论:细胞角蛋白8在细胞角蛋白中的高表达与骨髓转移有关。然而,vimentin本身的表达与骨髓转移没有任何关系。因此,为了揭示vimentin表达在乳腺癌进展和转移中的作用,还需要进一步的研究。(韩国乳腺癌协会杂志2003;6:14 . 8154)
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Co-relationship between Expression of Keratins and Vimentin in Breast Cancer Tissures and Metastases of Breast Cancer
학적 측면에서 최근들어 각광을 받게된 분야로서 조직특 significance indicating bone marrow micrometastases. However, The cases possesing cytokeratin 8, 18, and 19 expression, altogether 75% or more showed a significantly high risk to bone marrow micrometastases. In that cases, addition of vimentin expression allowed a more higher possibility of bone marrow micrometastases. Conclusion: A high expression of cytokeratin 8 among cytokeratins was related with bone marrow metastases. However, vimentin expression by itself did not show any realtionship with bone marrow metastases. So, a further study is needed in order to reveal the role of vimentin expression in progression and metastases of breast cancer. (Journal of Korean Breast Cancer Society 2003;6:148154)
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