Protective Effect of Curcuma domestica and Curcuma xanthorrhiza Extracts toward Kidney, Liver, and Pancreatic Organ Dysfunction in Streptozotocin-Induced Diabetes Mellitus Mice

The complications of Diabetes mellitus (DM) in Indonesia still need attention. Curcuma are often used as complementary medicine for antidiabetic. There is no study has been found comparing the effect of Curcuma domestica extracts (CDE) and Curcuma xanthorrhiza extracts (CXE) on the progression of the kidney, liver, and pancreas dysfunction in the mice with streptozotocin (STZ)-induced DM. This study was an experimental study to compare the effect of CDE and CXE on the progression of multi-organ dysfunction such as kidney, liver, and pancreas. The extract was produced by a maceration process with composition 100 gr simplicial and 300 ml ethanol 70%. The mice were induced with 180 mg/kgBW STZ intraperitoneally. The CDE and CXE were given 100 mg/kgBW orally for 21 days. A blood glucose was measured by a glucose meter on days 0, 1, and 21. The histopathological examination of the kidney, liver and pancreas were done on 21 days after the treatment. Data were analyzed using One Way ANOVA and Kruskal-Wallis tests (P <0.05). The results revealed that blood glucose levels showed no significant reduction of CDE and CXE after 21 days of the treatment. Histopathological examination showed a significant protection in kidney inflammation, kidney fibrosis, and pancreatic inflammation (P =0.001, P =0.013, P =0.027 respectively) in CDE and CXE groups. No significant differences were examined in liver inflammation, liver fibrosis, and pancreatic inflammation (P =0.184, P =0.498, P =0.193 respectively). However, there was a significant improvement in liver inflammation by CXE treatment (P =0.041). CXE has a greater potential for hepatoprotective effect compared to CDE. Keywords: Curcuma extract, Organ dysfunction, Inflammation, Diabetes mellitus, Mice