蛋白酶体激活剂REGγ在自身免疫性疾病中的作用

Clinical Immunology and Immunotherapy Pub Date : 2020-08-31 DOI:10.24966/ciit-8844/1000038

Xiaotao Li

{"title":"蛋白酶体激活剂REGγ在自身免疫性疾病中的作用","authors":"Xiaotao Li","doi":"10.24966/ciit-8844/1000038","DOIUrl":null,"url":null,"abstract":"disease with multiple systems and organs damaged [1]. Lupus Nephritis (LN) is one of the most serious complications in SLE and almost all SLE patients have varying degrees of renal lesions which directly affect the prognosis of SLE [2]. About 60% of SLE patients have LN, and 10%~30% of patients eventually develop renal failure [3]. The pathogenesis of SLE is complex and has yet to be clearly explained, resulting in a lack of effective targeted therapy in clinical practice.","PeriodicalId":370947,"journal":{"name":"Clinical Immunology and Immunotherapy","volume":"21 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Action Of The Proteasome Activator REGγ In Autoimmune Diseases\",\"authors\":\"Xiaotao Li\",\"doi\":\"10.24966/ciit-8844/1000038\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"disease with multiple systems and organs damaged [1]. Lupus Nephritis (LN) is one of the most serious complications in SLE and almost all SLE patients have varying degrees of renal lesions which directly affect the prognosis of SLE [2]. About 60% of SLE patients have LN, and 10%~30% of patients eventually develop renal failure [3]. The pathogenesis of SLE is complex and has yet to be clearly explained, resulting in a lack of effective targeted therapy in clinical practice.\",\"PeriodicalId\":370947,\"journal\":{\"name\":\"Clinical Immunology and Immunotherapy\",\"volume\":\"21 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Immunology and Immunotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24966/ciit-8844/1000038\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Immunology and Immunotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24966/ciit-8844/1000038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

多系统、多器官受损的疾病[1]。狼疮肾炎(Lupus nephroritis, LN)是SLE最严重的并发症之一，几乎所有SLE患者均有不同程度的肾脏病变，直接影响SLE的预后[2]。约60%的SLE患者有LN, 10%~30%的患者最终发展为肾功能衰竭[3]。SLE的发病机制复杂，尚未明确解释，导致临床缺乏有效的靶向治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Action Of The Proteasome Activator REGγ In Autoimmune Diseases

disease with multiple systems and organs damaged [1]. Lupus Nephritis (LN) is one of the most serious complications in SLE and almost all SLE patients have varying degrees of renal lesions which directly affect the prognosis of SLE [2]. About 60% of SLE patients have LN, and 10%~30% of patients eventually develop renal failure [3]. The pathogenesis of SLE is complex and has yet to be clearly explained, resulting in a lack of effective targeted therapy in clinical practice.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical Immunology and Immunotherapy

自引率

0.00%

发文量