人类乳头瘤病毒相关癌症的预防

S. Sarkar, Siddheesh Rajpurohit, S. Chauhan, Ashutosh Kumar Singh
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摘要

人乳头瘤病毒(HPV)感染上皮细胞,其复制周期与上皮细胞分化密切相关。粘膜感染性人乳头状瘤病毒的一个子集,也被称为“高风险”(HR)人乳头状瘤病毒,可引起宫颈疾病,可分为低级别或高级别。人乳头状瘤病毒相关感染可以影响生命的任何阶段,或者几个人可能在他们的一生中经历。我们强大的免疫系统在识别和清除病毒方面起着至关重要的作用,但有时我们需要强有力的治疗来消除或预防它。本文综述了预防HPV攻击宿主细胞的方法,包括疫苗接种或急性治疗。简短的概述也启发了发病机制,感染模式,以及基于证据的HPV和相关癌症的预防策略。
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Prevention Of Human Papillomavirus Associated Cancer
HPV (Human papillomavirus) infects epithelial cells, and their replication cycle is intimately linked to epithelial differentiation. A subset of mucosal-infective HPVs, also known as ‘high risk’ (HR) HPVs, causes cervical disease and could be classified as low or high grade. The HR-HPVs related infection can affect at any stage of life, or several individuals may experience during their lifetime. Our robust immune system plays a crucial role in recognizing and clearing the virus, but sometimes we need potent therapy to eliminate or prevent it. This review deals with the prevention of HPV from attacking host cells, and the methods may include vaccination or acute treatment. The short overview also enlightens the pathogenesis, mode of infection, and evidence-based prevention strategies of the HPV and associated cancer.
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