A Machine Learning Pipeline for Three-Way Classification of Alzheimer Patients from Structural Magnetic Resonance Images of the Brain

Magnetic resonance imaging (MRI) has emerged as an important tool to identify intermediate biomarkers of Alzheimer's disease (AD) due to its ability to measure regional changes in the brain that are thought to reflect disease severity and progression. In this paper, we set out a novel pipeline that uses volumetric MRI data collected from different subjects as input and classifies them into one of three classes: AD, mild cognitive impairment (MCI) and cognitively normal (CN). Our pipeline consists of three stages - (1) a segmentation layer where brain MRI data is divided into clinically relevant regions, (2) a classification layer that uses relational learning algorithms to make pair wise predictions between the three classes, and (3) a combination layer that combines the results of the different classes to obtain the final classification. One of the key features of our proposed approach is that it allows for domain expert's knowledge to guide the learning in all the layers. We evaluate our pipeline on 397 patients acquired from the Alzheimer's Disease Neuroimaging Initiative and demonstrate that it obtains state-of the-art performance with minimal feature engineering.