胆囊切除术标本良性组织病理病变谱

Prachi Singh, Faiyaz Ahmad, S. Dutta, S. Awasthi, V. Singh
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The study includes all radiologically confirmed inflammatory pathologies of including metaplastic changes of the gall bladder epithelium, irrespective of age and sex. The study excludes patients with evident gallbladder malignancy, cases with known secondaries from gall bladder, traumatic rupture of gallbladder. Results: The age of patients varied from 16 to 70 years, with a maximum number of patients (25%) belong to 31 to 40 years. Gall stones were associated with 59% cases of cholecystitis. Pigment stones were most common (74%). Histopathologically the most common diagnosis was chronic cholecystitis (69%). Conclusion: Almost all of the gallbladder lesions are inflammatory in origin, of which the most common disease being chronic cholecystitis. Chronic cholecystitis was found to be most probable diagnosis in a female of 30-40 years. Pigmented gall stones were found to be the most common etiology of chronic cholecystitis. 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摘要

背景:在任何组织病理学实验室最常收到的标本是胆囊切除术标本。大多数胆囊切除术是为了治疗胆石症。炎症可分为急性、慢性或急性上慢性。它几乎总是与胆结石有关,这是导致癌症的原因,如果诊断出早期预后良好的胆囊癌。因此,组织病理学检查是诊断早期癌的必要条件。对象和方法:选取100例不同年龄的胆囊切除术标本。所有标本均经过肉眼和显微镜检查。胆囊各层的组织学表现不同。该研究包括所有放射学证实的炎症病理,包括胆囊上皮化生变化,而不考虑年龄和性别。本研究排除了明显的胆囊恶性肿瘤患者、已知的胆囊继发病例、外伤性胆囊破裂病例。结果:患者年龄在16 ~ 70岁之间,31 ~ 40岁的患者最多,占25%。胆结石与59%的胆囊炎病例相关。色素结石最常见(74%)。组织病理学上最常见的诊断是慢性胆囊炎(69%)。结论:胆囊病变几乎都是炎症性的,其中以慢性胆囊炎最为常见。慢性胆囊炎最常见于30-40岁的女性。色素性胆结石是慢性胆囊炎最常见的病因。及时详细的组织病理学分析将有助于确认疾病的良性性质或发现任何恶性肿瘤的前兆。
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Spectrum of Benign Histopathological Lesions in Cholecystectomy Specimens
Background: The most commonly received specimen in any histopathology laboratory is cholecystectomy specimen. The majority of the cholecystectomies are done for Cholelithiasis. Inflammation may be acute, chronic or acute on chronic. It almost always occurs in association with gallstones, which is responsible for carcinoma and if the diagnosed early prognosis of the carcinoma gall bladder is good. Histopathological examination is therefore a must for diagnosis of early carcinomas. Subjects and Methods: 100 cholecystectomy specimens from patients       of all ages were included. All specimens were subjected to gross and microscopic assessment. Different histological findings were noted in various layers of the gall bladder. The study includes all radiologically confirmed inflammatory pathologies of including metaplastic changes of the gall bladder epithelium, irrespective of age and sex. The study excludes patients with evident gallbladder malignancy, cases with known secondaries from gall bladder, traumatic rupture of gallbladder. Results: The age of patients varied from 16 to 70 years, with a maximum number of patients (25%) belong to 31 to 40 years. Gall stones were associated with 59% cases of cholecystitis. Pigment stones were most common (74%). Histopathologically the most common diagnosis was chronic cholecystitis (69%). Conclusion: Almost all of the gallbladder lesions are inflammatory in origin, of which the most common disease being chronic cholecystitis. Chronic cholecystitis was found to be most probable diagnosis in a female of 30-40 years. Pigmented gall stones were found to be the most common etiology of chronic cholecystitis. Prompt detailed histopathological analysis will help to confirm the benign nature of the disease or to detect any precursors of malignancy.
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