基于正态分析的分子动力学转录协同性

D. D. Wang, Hong Yan, Qiang Be
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摘要

转录调控是遗传学的一个重要组成部分,转录因子和调控DNA区域参与了转录调控。在本文中,我们观察了两个重要的tf Oct-1和Sox-2在集体运动中增强子DNA结合位点的协同性。用正态分析(NMA)模拟了两种POU/HMG/DNA复合物的运动,并用分子动力学(MD)结果作为比较。在得到的这些运动中,我们发现了两种tf之间的几种合作相互作用。
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Transcriptional cooperativity in molecular dynamics based on normal mode analysis
Transcriptional regulation is an important component in genetics, with transcriptional factors (TFs) and regulatory DNA regions involved in. In this paper, we observe cooperativity between two significant TFs Oct-1 and Sox-2 at their enhancer DNA binding sites in collective motions. Normal mode analysis (NMA) is carried out to simulate the motions of two POU/HMG/DNA complexes, with molecular dynamics (MD) results used as a comparison. We have discovered several types of cooperative interactions between the two TFs in these obtained motions.
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