W. Khan, Y. Jia, F. Madi, A. Weber, Maysam Ghovanloo, Wen Li
{"title":"一种小型化、无线供电、反射器耦合的单通道光神经刺激器","authors":"W. Khan, Y. Jia, F. Madi, A. Weber, Maysam Ghovanloo, Wen Li","doi":"10.1109/MEMSYS.2018.8346512","DOIUrl":null,"url":null,"abstract":"We report a free-floating, wirelessly-powered, single channel opto neurostimulator consisting of a reflector-coupled microscale light emitting diode (μLED) and a mm-sized receiver (Rx) coil for untethered optogenetics neuromodulation. An optimized two-coil inductive link delivers over 4 mW instantaneous power at a low operating frequency to continuously drive the μLED while minimizing device invasiveness and tissue exposure to electromagnetic radiation. The reflector-coupled μLED enables significantly enhanced light intensity compared to a bare μLED. The temperature increase of the activated stimulators is <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the rat cortex, using c-Fos as a report of light-evoked neuronal activity.","PeriodicalId":400754,"journal":{"name":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"A miniaturized, wirelessly-powered, reflector-coupled single channel opto neurostimulator\",\"authors\":\"W. Khan, Y. Jia, F. Madi, A. Weber, Maysam Ghovanloo, Wen Li\",\"doi\":\"10.1109/MEMSYS.2018.8346512\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We report a free-floating, wirelessly-powered, single channel opto neurostimulator consisting of a reflector-coupled microscale light emitting diode (μLED) and a mm-sized receiver (Rx) coil for untethered optogenetics neuromodulation. An optimized two-coil inductive link delivers over 4 mW instantaneous power at a low operating frequency to continuously drive the μLED while minimizing device invasiveness and tissue exposure to electromagnetic radiation. The reflector-coupled μLED enables significantly enhanced light intensity compared to a bare μLED. The temperature increase of the activated stimulators is <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the rat cortex, using c-Fos as a report of light-evoked neuronal activity.\",\"PeriodicalId\":400754,\"journal\":{\"name\":\"2018 IEEE Micro Electro Mechanical Systems (MEMS)\",\"volume\":\"28 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2018 IEEE Micro Electro Mechanical Systems (MEMS)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/MEMSYS.2018.8346512\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 IEEE Micro Electro Mechanical Systems (MEMS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/MEMSYS.2018.8346512","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A miniaturized, wirelessly-powered, reflector-coupled single channel opto neurostimulator
We report a free-floating, wirelessly-powered, single channel opto neurostimulator consisting of a reflector-coupled microscale light emitting diode (μLED) and a mm-sized receiver (Rx) coil for untethered optogenetics neuromodulation. An optimized two-coil inductive link delivers over 4 mW instantaneous power at a low operating frequency to continuously drive the μLED while minimizing device invasiveness and tissue exposure to electromagnetic radiation. The reflector-coupled μLED enables significantly enhanced light intensity compared to a bare μLED. The temperature increase of the activated stimulators is <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the rat cortex, using c-Fos as a report of light-evoked neuronal activity.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
