柔性皮质内神经探针与可生物降解聚合物递送生物活性成分

Y. Kato, M. Nishino, I. Saito, T. Suzuki, K. Mabuchi
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引用次数: 14

摘要

开发了一种含有可生物降解聚合物的柔性皮质内神经探针,用于传递生物活性成分。这是为了促进植入神经探针周围受损神经组织的再生,以进行长期记录。神经探针是基于柔性和生物相容性的聚对二甲苯材料,并结合了给药系统(DDS)。设计了一种凹槽结构的探针,用于植入具有生物活性成分的可降解聚合物微球,促进受损组织的恢复,提高探针植入的机械刚度。通过体外PC12细胞实验,观察微球释放的神经生长因子(NGF)的作用。神经探针成功地插入大鼠的大脑皮层,并记录了神经信号。这些结果表明,柔性皮质内神经探针可以应用于慢性记录和神经再生
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Flexible Intracortical Neural Probe with Biodegradable Polymer for Delivering Bioactive Components
A flexible intracortical neural probe containing a biodegradable polymer for delivering bioactive components was developed. This was designed to promote regrowth of damaged neural tissues around the implanted neural probe for a long-term recording. The neural probe was based on the flexible and biocompatible material of parylene C incorporated a drug delivery system (DDS). A groove structure of the probe was designed to seed the degradable polymeric microspheres with bioactive components, to promote recovery of the damaged tissues, and improve mechanical stiffness for the probe implantation. The efficacy of released nerve growth factor (NGF) from the microspheres was observed in in vitro experiments with PC12 cells. The neural probe was successfully inserted in the cerebral cortex of a rat, and neural signals were recorded. These results have shown the possibility that the flexible intracortical neural probe can be applied for chronic recording along with neural regeneration
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