Effect Combination of Inspiratory Muscle Training and Aerobic Exercise on Cardiopulmonary Endurance and Pulmonary Function in Systemic Lupus Erythematosus

ABSTRACTIntroduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which decreased cardiopulmonary endurance and pulmonary function are the clinical manifestations. Inspiratory Muscle Training (IMT) has never been studied before, but aerobic exercise is commonly studied in SLE patients.This study was conducted to know the combination ef fect of IMT and aerobic exercise in SLE patients. Materials and methods: This study use quasi experimental design with pre and post-test approach. Fourteen SLE patients that included in the Lupus Low Disease Activity State (LLDAS) were givenIMT and aerobic exercise for 8 weeks. Cardiopulmonary endurance is measured by 6-minute walk test (6MWT) and Metabolic Equivalents (METs), pulmonary function by Maximal Inspiratory Pressure (MIP), Forced Expiratory Volume in 1 second (FEV1), and Forced Vital Capacity (FVC).Results: There is significant increase in pre and post intervention data, 397.45 ± 49.34 vs 427.50 ± 48.67 for 6MWT; 5.25 ± 1.14 vs 5.84 ± 1.08 for METs; 56.20 ± 14.24 vs 86.36 ± 20.73 for MIP; 68.00 ± 10.71 vs 72.90 ± 11.30 for FEV1; and 1.81 ± 1 1.14 vs 77.36 ± 11.80 for FVC.Conclusion: The combination of IMT and aerobic exercise can increase cardiopulmonary endurance and pulmonary function in SLE patients.Keywords: aerobic, inspiratory muscle training, lupus low disease activity state, maximal inspiratorypressure, metabolic equivalents, six-minute walk test.