海洋刺胞动物和腹足动物的毒素和毒液:针对离子通道的多样性和潜在药物

Sofiene Tlili, Raoua Ben Brahim, J. Sabatier, I. Regaya
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引用次数: 0

摘要

海洋无脊椎动物的多样性,如刺胞动物是大型生物活性分子的丰富来源。这种生物活性化合物的化学多样性在许多生物技术和治疗应用中具有广阔的潜力。在比较文献方法的基础上,我们打算在这篇综述中提出和讨论:i)作为生物活性分子生产候选的海洋无脊椎动物的多样性;Ii)生物活性化合物和源自这些生物的毒液的多样性;Iii)这些海洋生物的多样性与它们所分泌毒素的结构之间的关系。在本文的文献研究中,将重点研究靶向离子通道的蛋白质神经毒素。我们还讨论了刺胞动物的生物生态特性与毒素多样性之间的潜在联系。
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Toxins and venoms from marine cnidarians and gastropods: diversity and potential drugs targeting the ion channels
A diversity of marine invertebrates, such as cnidarians are rich sources of large bio-active molecules. This chemo-diversity of bio-active compounds has a promising potential in several biotechnological and therapeutic applications. On the basis of a comparative bibliographic approach, we intend in this review to present and discuss an overview of: i) the diversity of marine invertebrates as a candidate for bio-active molecules production; ii) the diversity of bio-active compounds and venom derived from these organisms; iii) the relationship between, the diversity of these marine organisms and the structure of the toxins they secrete. In this bibliographic study, a focus is going to be made on protein neurotoxins targeting ion channels. We also discuss the potential link between the bioecological characteristics of cnidarians and the diversity of toxins.
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