{"title":"血卟啉低聚物光动力治疗小鼠肿瘤细胞的电镜研究","authors":"H. Ikeda, A. Kitamura, A. Irie, T. Inokuchi","doi":"10.5984/jjpnsoclaserdent.9.2","DOIUrl":null,"url":null,"abstract":"A new photosensitizer Hematoporphyrin Oligomers (HpO) based photodynamic therapy (PDT) on mouse squamous cell carcinoma was studied. Morphological changes of the tumor after PDT was investigated by a transmission electron micros copy. One hour after PDT, bullous mitochondria were seen with irregular shaped inner cristae. After six hours, the inner cristae and outer membrane of mitochondria disappeared. Endonucleus vesicles appear ed. Heterochromatin increased in the nucleus. Forty-eight hours later, mitochondria had no longer its original feature. The outer layer of plasma membrane vanished away. Our study concludes that target organ HpO based PDT seems to be mitochondria. (J. Jpn. Soc. Laser Dent. 9:2-8, 1998 Reprint requests to Dr. IKEDA) Key words=Photodynamic therapy, Hematoporphyrin Oligomers, NR-S1 mouse squamous cell carcinoma キー ワー ド=光 化学 治療,ヘ マ トポル フ ィ リンオ リゴマ ー,NR-S1マ ウス扁 平上 皮癌","PeriodicalId":187459,"journal":{"name":"Journal of Japanese Society for Laser Dentistry","volume":"21 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electron Microscopic Study on Mouse Tumor Cell Following Photodynamic Therapy with Hematoporphyrin Oligomers\",\"authors\":\"H. Ikeda, A. Kitamura, A. Irie, T. Inokuchi\",\"doi\":\"10.5984/jjpnsoclaserdent.9.2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A new photosensitizer Hematoporphyrin Oligomers (HpO) based photodynamic therapy (PDT) on mouse squamous cell carcinoma was studied. Morphological changes of the tumor after PDT was investigated by a transmission electron micros copy. One hour after PDT, bullous mitochondria were seen with irregular shaped inner cristae. After six hours, the inner cristae and outer membrane of mitochondria disappeared. Endonucleus vesicles appear ed. Heterochromatin increased in the nucleus. Forty-eight hours later, mitochondria had no longer its original feature. The outer layer of plasma membrane vanished away. Our study concludes that target organ HpO based PDT seems to be mitochondria. (J. Jpn. Soc. Laser Dent. 9:2-8, 1998 Reprint requests to Dr. IKEDA) Key words=Photodynamic therapy, Hematoporphyrin Oligomers, NR-S1 mouse squamous cell carcinoma キー ワー ド=光 化学 治療,ヘ マ トポル フ ィ リンオ リゴマ ー,NR-S1マ ウス扁 平上 皮癌\",\"PeriodicalId\":187459,\"journal\":{\"name\":\"Journal of Japanese Society for Laser Dentistry\",\"volume\":\"21 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Japanese Society for Laser Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5984/jjpnsoclaserdent.9.2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Japanese Society for Laser Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5984/jjpnsoclaserdent.9.2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Electron Microscopic Study on Mouse Tumor Cell Following Photodynamic Therapy with Hematoporphyrin Oligomers
A new photosensitizer Hematoporphyrin Oligomers (HpO) based photodynamic therapy (PDT) on mouse squamous cell carcinoma was studied. Morphological changes of the tumor after PDT was investigated by a transmission electron micros copy. One hour after PDT, bullous mitochondria were seen with irregular shaped inner cristae. After six hours, the inner cristae and outer membrane of mitochondria disappeared. Endonucleus vesicles appear ed. Heterochromatin increased in the nucleus. Forty-eight hours later, mitochondria had no longer its original feature. The outer layer of plasma membrane vanished away. Our study concludes that target organ HpO based PDT seems to be mitochondria. (J. Jpn. Soc. Laser Dent. 9:2-8, 1998 Reprint requests to Dr. IKEDA) Key words=Photodynamic therapy, Hematoporphyrin Oligomers, NR-S1 mouse squamous cell carcinoma キー ワー ド=光 化学 治療,ヘ マ トポル フ ィ リンオ リゴマ ー,NR-S1マ ウス扁 平上 皮癌
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