潜在的抗肿瘤药物XVII(1).吲哚衍生物及其中间体的细胞毒性药物。

Acta pharmaceutica Nordica Pub Date : 1990-01-01

A Andreani, M Rambaldi, A Locatelli, F Andreani, P Aresca, R Bossa, I Galatulas

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摘要

新的吲哚衍生物及其中间体在P388白血病细胞培养中作为细胞毒性药物进行了测试。醛2a的活性高于硫代氨基脲3a、b和亚硝基脲14。氯乙酰基衍生物10,11是最有效的细胞毒性药物。

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Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates.

New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.

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Acta pharmaceutica Nordica

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