原癌基因c-fos在转基因小鼠中的诱导表达。

Archiv fur Geschwulstforschung Pub Date : 1990-01-01

D Bachiller, U Rüther

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引用次数: 0

摘要

我们在干扰素诱导的Mx启动子的控制下产生了表达原癌基因c-fos的转基因小鼠系。我们发现在骨骼肌、大脑和唾液腺中表达低，而在脾脏、肝脏、胸腺、心脏和肾脏中表达高。尽管这种转基因c-fos表达，我们尚未在这些小鼠系中检测到任何表型变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inducible expression of the proto-oncogene c-fos in transgenic mice.

We have generated transgenic mouse lines expressing the proto-oncogene c-fos under the control of the interferon inducible Mx promotor. We found low expression in skeletal muscle, brain and salivary glands and a very high expression in spleen, liver, thymus, heart and kidney. Despite this transgenic c-fos expression we have not yet detected any phenotypic changes in these mouse lines.

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Archiv fur Geschwulstforschung

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