三碘甲状腺原氨酸(T3)与胺碘酮在离体兔心脏灌注中的相互作用。

J P Kantelip, H Akdhim
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引用次数: 0

摘要

在离体灌注兔心脏中观察三碘甲状腺原氨酸(T3)给药(0,1 mg/kg/d) 5 d对胺碘酮(4,7,10 (-6)M)心肌摄取动力学和心电图效应的影响。通过绘制冠状窦流出物胺碘酮浓度时间数据确定药代动力学参数。用从T3预处理兔的心脏中取下的PR、QRS和QT心电图间期的百分比变化来测量心电图效应。含胺碘酮的改良Krebs Henseleit缓冲液灌注正常兔心脏后,PR、QRS和QT间期分别延长74%、76%和14%,而在T3预处理兔心脏中,胺碘酮可使PR延长84%;灌注60 min后,正常组和T3预处理组心肌胺碘酮浓度分别为260.6 +/- 20.9微克/g和235.6 +/- 11.9微克/g。两组心肌胺碘酮浓度与心电图对PR和QRS的影响呈线性关系。数据表明thyroïd激素T3不改变心肌摄取胺碘酮的动力学,但它确实改变了心电图效应。虽然T3增强了胺碘酮对PR的作用,但它降低了其对室内传导和心室复极的作用。
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Interactions between triiodothyronine (T3) and amiodarone in the isolated perfused rabbit heart.

The influence of 5 days' triiodothyronine (T3) administration (0,1 mg/kg/day) on myocardial uptake kinetics and electrocardiographic effects of amiodarone (4,7 10(-6)M) were examined in isolated perfused rabbit hearts. Pharmacokinetic parameters were determined by plotting the coronary sinus effluent amiodarone concentration time-data. Electrocardiographic effects were measured as percentage changes in PR, QRS and QT electrocardiogram intervals measured in hearts removed from T3 pretreated rabbits. The perfusion of normal rabbit hearts with a modified Krebs Henseleit buffer containing amiodarone prolonged PR, QRS and QT intervals by 74%, 76% and 14% respectively, while in T3 pretreated rabbit hearts, amiodarone induced a prolongation of 84% PR, 27% QRS and 9% QT. Myocardial amiodarone accumulation normalized for heart weight represented myocardial concentrations of 260.6 +/- 20.9 micrograms/g and 235.6 +/- 11.9 micrograms/g of tissue respectively in the normal and T3 pretreated groups after a 60 min perfusion. The relationship between myocardial amiodarone concentration and electrocardiographic effects on PR and QRS were linear in both groups. The data demonstrate that the thyroïd hormone T3 did not change the kinetics of the myocardial uptake of amiodarone, but that it did change the electrocardiographic effects. Although T3 potentialized the amiodarone effect on PR, it reduced its effect on intraventricular conduction and ventricular repolarisation.

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