罗马尼亚的利什曼病——工作假设

C. Caracoti, Alexandru Cristian Vasile Bugarin
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引用次数: 0

摘要

利什曼病有一种矛盾的名声,既是一种新出现的疾病,又是一种被忽视的疾病。如果我们看看一些临床形式的严重性,缺乏显微镜诊断培训,缺乏免疫测试试剂,在许多情况下治疗手段不稳定,以及发病率和死亡率数字,我们只能试图更好地理解和提供解决方案,以改善这种情况。在目前全球变暖、人道主义危机造成难民潮以及在一个沙蝇不受干扰地生活的国家存在潜在的犬利什曼病爆发的情况下,我认为这封信可能会增加对这种疾病的关注程度。利什曼病是指一组寄生虫病,由一种名为利什曼原虫的动质体鞭毛虫传播。已确认的属超过50个,但分类情况受到一系列争议。在20种最常见的物种中,超过一半是人畜共患的。原生动物引起三种主要病理形式:两种“旧世界”疾病,即内脏利什曼病(黑热/黑热病)和皮肤利什曼病(阿勒颇钮扣、比斯克拉钮扣、杰里科钮扣)以及美洲特有的皮肤粘膜利什曼病(也称为“新世界”疾病)。
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LEISHMANIASIS IN ROMANIA - WORK HYPOTHESIS
Leishmaniasis has the paradoxical reputation of being both an emerging and a neglected disease. If we look at the seriousness of some clinical forms, the lack of training in microscopic diagnosis, the lack of reagents for immunological tests and the precariousness of the therapeutic arsenal in many cases, as well as the morbidity and mortality figures, we can only try to better understand and offer solutions to improve the situation. In the current conditions of global warming, humanitarian crises that generate waves of refugees and the existence of latent outbreaks of canine leishmaniasis in a country where the sand fly lives undisturbed, I believe that this letter could increase the degree of concern about this disease. Leishmaniasis refers to a group of parasitic diseases transmitted by a kinetoplastid flagellate named Leishmania. More than 50 genera are recognized, but the taxonomic situation is subject to a series of controversies. Of the 20 most frequently encountered species over half are zoonotic. The protozoan causes three primary pathological forms: the two “Old World” diseases known as visceral leishmaniasis (black fever/kala azar) and cutaneous leishmaniasis (Aleppo button, Biskra button, Jericho button) as well as mucocutaneous leishmaniasis which is specific to the Americas (also called the “New World” diseases).
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