面向高灵敏度生物传感的等离子体光纤尖端优化设计的数值模型

M. Vidal, A. Assunção, M. Facão, C. Leitão
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引用次数: 0

摘要

由于光纤具有体积小、重量轻、灵活和电气安全等优点,因此已被探索作为传感器应用于不同领域,包括诊断、食品安全和环境监测。特别是基于表面等离子体共振(SPR)的光纤生物传感器,由于其快速、无标记和高灵敏度的传感能力而被广泛报道。其中,等离子体无包层尖端是一种经济有效的工具,其光被光纤端面的金属反射,引发SPR并使光路加倍。Tips因其灵敏度、便携性和机械强度而受到认可,与易碎或不太紧凑的传感器相比,它更适合于原位传感。在这项工作中,建立了一个数值模型来模拟镀金尖端(au -tip)的SPR曲线,以便容易地预测其优化设计参数,从而提高其灵敏度。该算法利用三层菲涅耳p偏振方程确定了反射功率,并模拟了传感区域周围不同折射率溶液的SPR响应。然后通过灵敏度的测定来评估其性能。通过这种方法,建立了传感器性能与其参数之间的关系,即传感区域长度与芯直径、数值孔径和Au厚度的比值。这种简单的方法为au尖端传感器提供了理想的设计参数,该传感器可用于RI监测和高灵敏度的生物传感器。
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Numerical model to optimize the design of plasmonic optical fiber tips towards highly sensitive biosensing
Optical fibers have been explored as sensors for application in different fields, including diagnostics, food security, and environmental monitoring, due to their low size and weight, flexibility and electrical safety. Particularly, optical fiber biosensors based on surface plasmon resonance (SPR) are broadly reported given their rapid, label-free and highly sensitive sensing ability. Among them, plasmonic unclad tips are a cost-effective tool, in which light is reflected by the metal at the fiber end-face, eliciting SPR and doubling the optical path. Tips are recognized for their sensitivity, portability and mechanical strength, being more suitable for in-situ sensing compared to fragile or less compact sensors. In this work, a numerical model was developed to simulate the SPR curve of Au-coated tips (Au-tips) to readily predict their optimized design parameters and therefore enhance their sensitivity. The algorithm determined the reflected power using the three-layer Fresnel equation for p-polarization, with the SPR response being simulated for solutions with different refractive index (RI) surrounding the sensing area. The performance was then assessed by determination of the sensitivity. This way, a relationship was established between the sensor’s performance and its parameters, namely, the ratio between sensing region length and core diameter, numerical aperture and Au thickness. This simple method provided the idealized design parameters for an Au-tip sensor, which might have application for RI monitoring and as a highly sensitive biosensor.
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