H J Koch, U Wollina, M Seyfarth, W Thiel, H Schaarschmidt
{"title":"寻常型银屑病患者病变皮肤及血清中IgA的检测。","authors":"H J Koch, U Wollina, M Seyfarth, W Thiel, H Schaarschmidt","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Origin and function of IgA in the psoriatic skin are unknown. Including a monoclonal antibody against the secretory component (SC) of the secretory IgA (SIga), we have tried to characterize the IgA in psoriasis. With help of a polyclonal antiserum we found depots of IgA in the skin in 69% of all investigated patients. There was a correlation between the degree of akanthosis and the amount of intraepidermal IgA. In the serum of the psoriasis total IgA was significant increased, but never we found SC-bound SIgA in the skin or elevated levels in serum of patients.</p>","PeriodicalId":11046,"journal":{"name":"Dermatologische Monatschrift","volume":"176 4","pages":"225-31"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Detection of IgA in diseased skin and serum of patients with psoriasis vulgaris].\",\"authors\":\"H J Koch, U Wollina, M Seyfarth, W Thiel, H Schaarschmidt\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Origin and function of IgA in the psoriatic skin are unknown. Including a monoclonal antibody against the secretory component (SC) of the secretory IgA (SIga), we have tried to characterize the IgA in psoriasis. With help of a polyclonal antiserum we found depots of IgA in the skin in 69% of all investigated patients. There was a correlation between the degree of akanthosis and the amount of intraepidermal IgA. In the serum of the psoriasis total IgA was significant increased, but never we found SC-bound SIgA in the skin or elevated levels in serum of patients.</p>\",\"PeriodicalId\":11046,\"journal\":{\"name\":\"Dermatologische Monatschrift\",\"volume\":\"176 4\",\"pages\":\"225-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatologische Monatschrift\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatologische Monatschrift","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Detection of IgA in diseased skin and serum of patients with psoriasis vulgaris].
Origin and function of IgA in the psoriatic skin are unknown. Including a monoclonal antibody against the secretory component (SC) of the secretory IgA (SIga), we have tried to characterize the IgA in psoriasis. With help of a polyclonal antiserum we found depots of IgA in the skin in 69% of all investigated patients. There was a correlation between the degree of akanthosis and the amount of intraepidermal IgA. In the serum of the psoriasis total IgA was significant increased, but never we found SC-bound SIgA in the skin or elevated levels in serum of patients.
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