氟西汀及其两个对映体作为选择性血清素摄取抑制剂。

Acta pharmaceutica Nordica Pub Date : 1990-01-01

D T Wong, R W Fuller, D W Robertson

{"title":"氟西汀及其两个对映体作为选择性血清素摄取抑制剂。","authors":"D T Wong, R W Fuller, D W Robertson","doi":"","DOIUrl":null,"url":null,"abstract":"The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.","PeriodicalId":7082,"journal":{"name":"Acta pharmaceutica Nordica","volume":"2 3","pages":"171-80"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.\",\"authors\":\"D T Wong, R W Fuller, D W Robertson\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.\",\"PeriodicalId\":7082,\"journal\":{\"name\":\"Acta pharmaceutica Nordica\",\"volume\":\"2 3\",\"pages\":\"171-80\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta pharmaceutica Nordica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta pharmaceutica Nordica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

对R,S-氟西汀及其R和S对映体的生化和药理学特性进行了比较和综述。这两种对映体在体外和体内表现出类似于R, s -氟西汀的5 -羟色胺摄取抑制剂的特征，其效价大致相等或具有接近统一的感染比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.

The biochemical and pharmacological profiles of R,S-fluoxetine and its R and S enantiomers have been compared and reviewed. Both enantiomers exhibit profiles analogous to R,S-fluoxetine as inhibitors of serotonin uptake in vitro and in vivo with about equal potencies or a eudismic ratio near unity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Acta pharmaceutica Nordica

自引率

0.00%

发文量