模块化聚酮合酶

R. Dieckmann, T. Schwecke
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引用次数: 2

摘要

红霉素生物合成;红霉素基因群;debs -蛋白;雷帕霉素生物合成基因群;其他模块化聚酮合成酶NRPS/PKS杂交体;通过基因工程产生新型聚酮;硫酯酶结构域的重新定位;红霉素;雷帕霉素;非核糖体肽合成酶;组合生物合成;混合动力系统
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Modular Polyketide Synthases
Introduction Historical Outline Erythromycin Biosynthesis The Erythromycin Gene Cluster The DEBS-Proteins The Biosynthetic Gene Cluster for Rapamycin Other Modular Polyketide Synthases NRPS/PKS Hybrids Generation of Novel Polyketides via Genetic Engineering Relocation of the Thioesterase Domain Domain Swapping Recombination of Modules Outlook and Perspectives Keywords: polyketide synthase; erythromycin; rapamycin; non-ribosomal peptide synthetase; combinatorial biosynthesis; hybrid system
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