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{"title":"模块化聚酮合酶","authors":"R. Dieckmann, T. Schwecke","doi":"10.1002/3527600035.BPOL9005","DOIUrl":null,"url":null,"abstract":"Introduction \nHistorical Outline \nErythromycin Biosynthesis \nThe Erythromycin Gene Cluster \nThe DEBS-Proteins \n \n \nThe Biosynthetic Gene Cluster for Rapamycin \nOther Modular Polyketide Synthases \nNRPS/PKS Hybrids \nGeneration of Novel Polyketides via Genetic Engineering \nRelocation of the Thioesterase Domain \nDomain Swapping \nRecombination of Modules \n \n \nOutlook and Perspectives \n \n \nKeywords: \n \npolyketide synthase; \nerythromycin; \nrapamycin; \nnon-ribosomal peptide synthetase; \ncombinatorial biosynthesis; \nhybrid system","PeriodicalId":165163,"journal":{"name":"Biopolymers Online","volume":"183 ","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2002-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Modular Polyketide Synthases\",\"authors\":\"R. Dieckmann, T. Schwecke\",\"doi\":\"10.1002/3527600035.BPOL9005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction \\nHistorical Outline \\nErythromycin Biosynthesis \\nThe Erythromycin Gene Cluster \\nThe DEBS-Proteins \\n \\n \\nThe Biosynthetic Gene Cluster for Rapamycin \\nOther Modular Polyketide Synthases \\nNRPS/PKS Hybrids \\nGeneration of Novel Polyketides via Genetic Engineering \\nRelocation of the Thioesterase Domain \\nDomain Swapping \\nRecombination of Modules \\n \\n \\nOutlook and Perspectives \\n \\n \\nKeywords: \\n \\npolyketide synthase; \\nerythromycin; \\nrapamycin; \\nnon-ribosomal peptide synthetase; \\ncombinatorial biosynthesis; \\nhybrid system\",\"PeriodicalId\":165163,\"journal\":{\"name\":\"Biopolymers Online\",\"volume\":\"183 \",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biopolymers Online\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/3527600035.BPOL9005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biopolymers Online","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/3527600035.BPOL9005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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