Silencing BAG3 Inhibits Tumor Cell Proliferation by reducing the Activation of ERK in TNBC

Triple-negative breast cancer has high reoccurrence rates after chemotherapy treatment. This kind of cancer easily transfers from its first position to other organs, and the death rates increase a lot during this process. New therapies targeting multiple signaling nodes are being explored nowadays. Previous studies have reported that BAG3 can interact with components of a different signaling pathway to promote tumor cell proliferation. In this paper, we explored whether protein ERK1/2, a component in the EGFR pathway, has a physical interaction with BAG3 and the effect of silencing BAG3 using SiBAG3 on activating ERK1/2 and tumor cell proliferation in vivo conditions. Six possible results are proposed to illustrate the relation between BAG3, ERK, and tumor cell proliferation. The study's results will provide theoretical evidence on whether preventing the interaction between BAG3 and ERK could be a potential treatment method for TNBC.