{"title":"稳定同位素13C导致所有癌症的证据","authors":"Reginald B. Little","doi":"10.24018/ejphysics.2022.4.4.187","DOIUrl":null,"url":null,"abstract":"Evidence for a general mechanism of genesis of all cancers is given by presenting a puzzle and using recent results of aspartame and acesulfame-K to fit the pieces of the cancer puzzle together for proof of the mechanism of oncogenesis. Aspartame and acesulfame-K have been linked to cancer. Aspartame is a modified dipeptide (methylated phenylalanine (modified) and aspartic acid), so modified amino acids were thought to be more innocuous. The author previously noted isotopically enriched and/or clumped bond-specific amino acids and oligonucleotides have different biochemical reactions for different biology. Acesulfame-K is not a peptide or oligonucleotide but it has some similar chemical structure to oligonucleoside and reversibly decomposes to affect oligonucleosides and affect cells and bacteria cells like E Coli for producing isotopically enriched amino acids indirectly. E. Coli is present in the human digestive system and is known to accelerate stable isotope enrichment of amino acids with 13C, 15N, and/or 17O. Thereby acesulfame-K and aspartame induce isotopic enrichments and excessive 13C, 15N, and/or 17O introductions into proteins and nucleic acids. Such effects of 13C isotopes as induced by the bacteria and these chemicals like aspartame and acesulfame-K may be coupled to effects of static magnetic field(s) and radio frequency electromagnetic waves for explaining the complexity of results and inconsistent results from separating these effects. Thereby the 13C isotope enriched phenylalanine and/or aspartic acid may be the basis of malfunctioning normal cells for the genesis of cancer. Further support for this theory of 13C causing cancer by ingestion of aspartame is given by also noting the mystery and confounding results of monosodium glutamate causing cancer as the glutamate is synthesized by bacterial culture and the resulting ingested glutamic acid enriched with 13C and 15N and possibly 17O causes adverse biochemistry and enzymatics (relative to glutamate from healthy plants and animals rather than the bacterial industrial glutamate in MSG) for cancer and other diseases as explaining the observation of cancer and other diseases from acute and chronic MSG ingestion over months and years. The third case of bacterial production of insulin during the last 25 years for recent correlation to insulin causing cancer relative to less cancer from older methods of insulin production is more evidence of bacterial production of amino acids and peptides causing enriched heavy isotopes and the resulting enriched amino acids and peptides causing cancer relative to ingestion of 13C enriched carbohydrates.","PeriodicalId":292629,"journal":{"name":"European Journal of Applied Physics","volume":"158 2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evidence of Stable Isotope 13C Causing All Cancers\",\"authors\":\"Reginald B. Little\",\"doi\":\"10.24018/ejphysics.2022.4.4.187\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Evidence for a general mechanism of genesis of all cancers is given by presenting a puzzle and using recent results of aspartame and acesulfame-K to fit the pieces of the cancer puzzle together for proof of the mechanism of oncogenesis. Aspartame and acesulfame-K have been linked to cancer. Aspartame is a modified dipeptide (methylated phenylalanine (modified) and aspartic acid), so modified amino acids were thought to be more innocuous. The author previously noted isotopically enriched and/or clumped bond-specific amino acids and oligonucleotides have different biochemical reactions for different biology. Acesulfame-K is not a peptide or oligonucleotide but it has some similar chemical structure to oligonucleoside and reversibly decomposes to affect oligonucleosides and affect cells and bacteria cells like E Coli for producing isotopically enriched amino acids indirectly. E. Coli is present in the human digestive system and is known to accelerate stable isotope enrichment of amino acids with 13C, 15N, and/or 17O. Thereby acesulfame-K and aspartame induce isotopic enrichments and excessive 13C, 15N, and/or 17O introductions into proteins and nucleic acids. Such effects of 13C isotopes as induced by the bacteria and these chemicals like aspartame and acesulfame-K may be coupled to effects of static magnetic field(s) and radio frequency electromagnetic waves for explaining the complexity of results and inconsistent results from separating these effects. Thereby the 13C isotope enriched phenylalanine and/or aspartic acid may be the basis of malfunctioning normal cells for the genesis of cancer. Further support for this theory of 13C causing cancer by ingestion of aspartame is given by also noting the mystery and confounding results of monosodium glutamate causing cancer as the glutamate is synthesized by bacterial culture and the resulting ingested glutamic acid enriched with 13C and 15N and possibly 17O causes adverse biochemistry and enzymatics (relative to glutamate from healthy plants and animals rather than the bacterial industrial glutamate in MSG) for cancer and other diseases as explaining the observation of cancer and other diseases from acute and chronic MSG ingestion over months and years. The third case of bacterial production of insulin during the last 25 years for recent correlation to insulin causing cancer relative to less cancer from older methods of insulin production is more evidence of bacterial production of amino acids and peptides causing enriched heavy isotopes and the resulting enriched amino acids and peptides causing cancer relative to ingestion of 13C enriched carbohydrates.\",\"PeriodicalId\":292629,\"journal\":{\"name\":\"European Journal of Applied Physics\",\"volume\":\"158 2 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Applied Physics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24018/ejphysics.2022.4.4.187\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Applied Physics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24018/ejphysics.2022.4.4.187","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evidence of Stable Isotope 13C Causing All Cancers
Evidence for a general mechanism of genesis of all cancers is given by presenting a puzzle and using recent results of aspartame and acesulfame-K to fit the pieces of the cancer puzzle together for proof of the mechanism of oncogenesis. Aspartame and acesulfame-K have been linked to cancer. Aspartame is a modified dipeptide (methylated phenylalanine (modified) and aspartic acid), so modified amino acids were thought to be more innocuous. The author previously noted isotopically enriched and/or clumped bond-specific amino acids and oligonucleotides have different biochemical reactions for different biology. Acesulfame-K is not a peptide or oligonucleotide but it has some similar chemical structure to oligonucleoside and reversibly decomposes to affect oligonucleosides and affect cells and bacteria cells like E Coli for producing isotopically enriched amino acids indirectly. E. Coli is present in the human digestive system and is known to accelerate stable isotope enrichment of amino acids with 13C, 15N, and/or 17O. Thereby acesulfame-K and aspartame induce isotopic enrichments and excessive 13C, 15N, and/or 17O introductions into proteins and nucleic acids. Such effects of 13C isotopes as induced by the bacteria and these chemicals like aspartame and acesulfame-K may be coupled to effects of static magnetic field(s) and radio frequency electromagnetic waves for explaining the complexity of results and inconsistent results from separating these effects. Thereby the 13C isotope enriched phenylalanine and/or aspartic acid may be the basis of malfunctioning normal cells for the genesis of cancer. Further support for this theory of 13C causing cancer by ingestion of aspartame is given by also noting the mystery and confounding results of monosodium glutamate causing cancer as the glutamate is synthesized by bacterial culture and the resulting ingested glutamic acid enriched with 13C and 15N and possibly 17O causes adverse biochemistry and enzymatics (relative to glutamate from healthy plants and animals rather than the bacterial industrial glutamate in MSG) for cancer and other diseases as explaining the observation of cancer and other diseases from acute and chronic MSG ingestion over months and years. The third case of bacterial production of insulin during the last 25 years for recent correlation to insulin causing cancer relative to less cancer from older methods of insulin production is more evidence of bacterial production of amino acids and peptides causing enriched heavy isotopes and the resulting enriched amino acids and peptides causing cancer relative to ingestion of 13C enriched carbohydrates.