N-CWS诱导肿瘤浸润细胞的特性。

Y Yasutomi, M Onuma, W C Davis, Y Kawakami
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引用次数: 0

摘要

瘤内注射红诺卡菌细胞壁骨架(N-CWS)后细胞表面标志物分析显示,巨噬细胞、Pan T和BoCD4+细胞百分比逐渐升高。BoCD8+细胞比例从注射后第4天开始逐渐升高,第8天开始下降。注射N-CWS后8 d淋巴结节中获得的新鲜肿瘤浸润细胞对牛白血病细胞株具有细胞毒活性,但随着培养时间的延长,细胞毒活性降低,培养14 d后未检测到细胞毒活性。每隔一周将培养的淋巴细胞两次注射到淋巴结节中进行过继免疫治疗,第一次注射后5周淋巴结节完全消退。
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Properties of tumor infiltrated cells induced by N-CWS.

Analysis of surface marker of cells after intratumor injection with Nocardia rubra cell wall skeleton (N-CWS) resulted in gradually increasing percentage of macrophage, Pan T and BoCD4+ cells. Proportion of BoCD8+ cells gradually increased from 4th day and then decreased from 8th day after the injection. Fresh tumor infiltrated cells obtained from lymphatic nodule at 8 days after injection of N-CWS showed cytotoxic activity against bovine leukemia cell line, but this activity decreased with the time of cultivation and no activity could be detected after 14 days cultivation. These cultured cells were injected twice to lymphatic nodule at one week interval for adoptive immunotherapy and found to induce complete regression of nodule after 5 weeks from first injection.

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