UJI ANTI INFLAMASI SECARA TOPIKAL EKSTRAK ETANOL UMBI SARANG SEMUT (Myrmecodia tuberosa Jack) PADA MENCIT PUTIH JANTAN

Inflammation  is a tissue response  towards  damaging  physical  or chemical  stimulations.  One local sign of inflammation  is  edema  (tumor).  Usage  of  natural  herbal  medicine  has  become  an  alternative  way  to  prevent inflammation.  The extract of umbi sarang semut (Myrmecodia  tuberosa Jack) has anti-inflammation,  anti-bacterial and  antioxidant  properties.  This  study  is  to  determine  the  anti-inflammation  effect  of  the  topical  application  of Myrmecodia  tuberosa Jack ethanol extract. This study used 28 white male rats previously  induced with carragenin 2%  b/v  0,5ml  and  divided  into  4  treatment  groups.  Groups  1,2  dan  3  were  given  the  ethanol  extract  with  a concentration  of 0,5 %; 1%; 2% respectively  after induction and on 24, 48 and 72 hours after the first application. Group 4 was the untreated control group. Each treatment group were extracted for their inflammation  exudate fluid from their backs using a 1 ml syringe. Edema fluid volume was measured. The results showed a decrease of edema fluid volume on all treatment groups.   Statistical data analysis showed a significant difference between group 2 and the negative  control;  also between  group  3 and the negative  control.  In conclusion,  the topical  ethanol  extract  of Myrmecodia tuberosa Jack can reduce inflammation reactions. Keywords: Myrmecodia  tuberosa  Jack, anti-inflammation,  topical, edema fluid volume