Activated Macrophage and Granulomatous Inflammation

The granulomatous inflammation is a characteristic type of chronic inflammation in which main cells are macrophages, multinucleated cells and epithelioid cells. The dynamic structure of granuloma helps to defend the body from microbiological threats. Granulomatous inflammation is a histologic pattern of tissue reactions which appears following cell damage. A variety of systemic diseases are occurred by this special inflammatory response. The granulomatous inflammatory response is common in many infective, allergic, autoimmune, toxic and neoplastic diseases. Mechanism that regulates granulomatous inflammation is remain not properly understood. The pulmonary system is one of the most common concerned sites to face the granulomatous inflammation. Unlike the lungs, skin can be affected by different ways including direct inoculation, endogenous origins and hematogenous spread. In this theory, we discuss about formation of granuloma, and that the granulomatous inflammation is a protective mechanism of our body but sometimes it can also cause serious and severe diseases in different body organs.