首页 > 最新文献

International Journal of Pulmonary & Respiratory Sciences最新文献

英文 中文
Idiopathic Pulmonary Fibrosis in A Young Patient with Strong Family Background 具有强烈家庭背景的年轻患者的特发性肺纤维化
Pub Date : 2022-02-11 DOI: 10.19080/ijoprs.2022.05.555670
Ralph Nehme
Background: Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. It’s a chronic, progressive and often fatal disease. The etiology, pathophysiology and predisposing factors of IPF are still not fully understood. Genetic mutations leading to the disease are sometimes among the underlying predisposing factors leading to the entity known as familial pulmonary fibrosis (FPF). FPF is a rare entity and often overlooked. Not much data is available on the subject in the literature. For that reason, it’s important to increase awareness about this disease. Case presentation: In the following article, we report the case of a young patient presenting with a fibrosing lung disease that turns out being a familial pulmonary fibrosis. This case report goes over the challenges faced with the diagnosis, the approach for treatment and the genetic counseling in FPF. Conclusion: FPF is a rare disease with potential severe consequences for the patient. A high level of suspicions is required when making the diagnosis and potential genetic testing of family members might be required.
背景:特发性肺纤维化(IPF)是肺间质性疾病最常见的形式。这是一种慢性、进行性且往往致命的疾病。IPF的病因、病理生理及易感因素尚不完全清楚。导致该疾病的基因突变有时是导致家族性肺纤维化(FPF)的潜在易感因素之一。FPF是一个罕见的实体,经常被忽视。文献中关于这一主题的数据不多。因此,提高对这种疾病的认识是很重要的。病例介绍:在下面的文章中,我们报告了一个年轻患者的病例表现为纤维化肺部疾病,结果是家族性肺纤维化。本病例报告讨论了FPF在诊断、治疗方法和遗传咨询方面面临的挑战。结论:FPF是一种罕见的疾病,对患者有潜在的严重后果。诊断时需要高度怀疑,可能需要对家庭成员进行潜在的基因检测。
{"title":"Idiopathic Pulmonary Fibrosis in A Young Patient with Strong Family Background","authors":"Ralph Nehme","doi":"10.19080/ijoprs.2022.05.555670","DOIUrl":"https://doi.org/10.19080/ijoprs.2022.05.555670","url":null,"abstract":"Background: Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. It’s a chronic, progressive and often fatal disease. The etiology, pathophysiology and predisposing factors of IPF are still not fully understood. Genetic mutations leading to the disease are sometimes among the underlying predisposing factors leading to the entity known as familial pulmonary fibrosis (FPF). FPF is a rare entity and often overlooked. Not much data is available on the subject in the literature. For that reason, it’s important to increase awareness about this disease. Case presentation: In the following article, we report the case of a young patient presenting with a fibrosing lung disease that turns out being a familial pulmonary fibrosis. This case report goes over the challenges faced with the diagnosis, the approach for treatment and the genetic counseling in FPF. Conclusion: FPF is a rare disease with potential severe consequences for the patient. A high level of suspicions is required when making the diagnosis and potential genetic testing of family members might be required.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126083988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent Silent Coronary Spasm with Variant Premature Ventricular Contractions, and QRS-Complex Fragmentation in COVID-19 Pneumonia with Stroke and Pleural Effusion; Serious Risk but a Good Outcome 新型冠状病毒肺炎合并脑卒中和胸腔积液患者间歇性无症状冠状动脉痉挛伴变异性室性早搏及qrs复合碎片化风险很大,但结果很好
Pub Date : 2022-01-24 DOI: 10.19080/ijoprs.2022.05.555669
Yasser Mohammed Hassanain Elsayed
Rationale : A pandemic COVID-19 virus is a multi-systemic lethal worldwide infection. Cardiac, neurological, chest, and renal systems are frequently involved. Silent coronary artery disease is sometimes reported in diabetic and elderly patients. There is a strong correlation between COVID-19 pneumonia, thromboembolism, and ischemic heart disease. Ischemic stroke and coronary artery disease are commonly clinically recognized in COVID-19 patients who have a risk impact on both morbidity and mortality. The QRS-complex fragmentation is considered as a marker for cardiac structural diseases inducing biventricular hypertrophy or any condition interfering with the normal homogeneous depolarization status inside the myocardium. Patient concerns: A 68-year-old, non-working, smoker, married, Egyptian male patient was admitted to the intensive care unit with cerebrovascular stroke, premature ventricular contractions, and COVID-19 pneumonia. Diagnosis: Intermittent silent coronary spasm with ischemic variant premature ventricular contractions, and QRS-complex fragmentation in COVID-19 pneumonia with stroke and pleural effusion. Interventions: Electrocardiography, oxygenation, non-contrast chest CT, and brain CT. Outcomes: Good response and better outcomes despite the presence of several remarkable risk factors were the results. Lessons: Intermittent silent coronary spasm is an interesting issue and maybe multi-factorial. The presence of elderly male sex, heavy smoker, COVID-19 pneumonia, pleural effusion, recurrent ischemic cerebrovascular stroke, renal impairment, ischemic heart disease, hypocalcemia, diabetes, ischemic variant premature ventricular contractions, and QRS-complex fragmentations are prognostic factors for the severity of the disease. The clinical and electrocardiographic response after using anti-COVID19 measures the signifying its role and suggests the diagnosis of COVID19 infection.
理由:COVID-19大流行病毒是一种多系统的全球性致命感染。心脏、神经系统、胸部和肾脏系统经常受到影响。隐匿性冠状动脉疾病有时见于糖尿病和老年患者。COVID-19肺炎、血栓栓塞和缺血性心脏病之间存在很强的相关性。缺血性卒中和冠状动脉疾病是临床上普遍认为的COVID-19患者,对发病率和死亡率都有风险影响。qrs复合体碎片被认为是心脏结构性疾病引起双心室肥厚或任何干扰心肌内正常均匀去极化状态的疾病的标志。患者关注:68岁,无工作,吸烟,已婚,埃及男性患者,因脑血管卒中,室性早缩和COVID-19肺炎入住重症监护病房。诊断:新型冠状病毒肺炎合并脑卒中和胸腔积液患者间歇性无症状冠状动脉痉挛伴缺血性变异型室性早搏,qrs复合物碎裂。干预措施:心电图、氧合、胸部非对比CT和脑部CT。结果:尽管存在几个显著的危险因素,但结果是良好的反应和更好的结果。教训:间歇性无症状冠状动脉痉挛是一个有趣的问题,可能是多因素的。老年男性、重度吸烟者、新型冠状病毒肺炎、胸腔积液、复发性缺血性脑血管卒中、肾功能损害、缺血性心脏病、低钙血症、糖尿病、缺血性变异性室性早搏、qrs复合物碎片化是影响病情严重程度的预后因素。使用抗新冠病毒药物后的临床和心电图反应可显示其作用,为诊断新冠病毒感染提供依据。
{"title":"Intermittent Silent Coronary Spasm with Variant Premature Ventricular Contractions, and QRS-Complex Fragmentation in COVID-19 Pneumonia with Stroke and Pleural Effusion; Serious Risk but a Good Outcome","authors":"Yasser Mohammed Hassanain Elsayed","doi":"10.19080/ijoprs.2022.05.555669","DOIUrl":"https://doi.org/10.19080/ijoprs.2022.05.555669","url":null,"abstract":"Rationale : A pandemic COVID-19 virus is a multi-systemic lethal worldwide infection. Cardiac, neurological, chest, and renal systems are frequently involved. Silent coronary artery disease is sometimes reported in diabetic and elderly patients. There is a strong correlation between COVID-19 pneumonia, thromboembolism, and ischemic heart disease. Ischemic stroke and coronary artery disease are commonly clinically recognized in COVID-19 patients who have a risk impact on both morbidity and mortality. The QRS-complex fragmentation is considered as a marker for cardiac structural diseases inducing biventricular hypertrophy or any condition interfering with the normal homogeneous depolarization status inside the myocardium. Patient concerns: A 68-year-old, non-working, smoker, married, Egyptian male patient was admitted to the intensive care unit with cerebrovascular stroke, premature ventricular contractions, and COVID-19 pneumonia. Diagnosis: Intermittent silent coronary spasm with ischemic variant premature ventricular contractions, and QRS-complex fragmentation in COVID-19 pneumonia with stroke and pleural effusion. Interventions: Electrocardiography, oxygenation, non-contrast chest CT, and brain CT. Outcomes: Good response and better outcomes despite the presence of several remarkable risk factors were the results. Lessons: Intermittent silent coronary spasm is an interesting issue and maybe multi-factorial. The presence of elderly male sex, heavy smoker, COVID-19 pneumonia, pleural effusion, recurrent ischemic cerebrovascular stroke, renal impairment, ischemic heart disease, hypocalcemia, diabetes, ischemic variant premature ventricular contractions, and QRS-complex fragmentations are prognostic factors for the severity of the disease. The clinical and electrocardiographic response after using anti-COVID19 measures the signifying its role and suggests the diagnosis of COVID19 infection.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121707013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Case of Trapped Lung Cause by Chronic Pleural Effusion: Another Etiology of This Uncommon Disease 慢性胸腔积液致陷肺一例:此病的另一病因
Pub Date : 2022-01-18 DOI: 10.19080/ijoprs.2022.05.555668
Hardik A. Fichadiya
Trapped lung is defined by the inability of the lung to expand and fill the thoracic cavity. It is an outcome of fibrosis and thickening of visceral pleural preventing lung re-expansion. We present a 62 -year-old women with past medical history of chronic kidney disease and heart failure with preserved ejection fraction who presented with bilateral pleural effusions. Effusion on the right side was tapped draining a transudative fluid. Chest X ray on the following day showed a pneumothorax at the right lung base, the margins of which coincided which that of the effusion. The following day she now developed a hydro-pneumothorax in the same location. One rare yet reported cause of trapped lung is chronic pleural effusions in the setting of decompensated heart failure.
困肺的定义是肺不能扩张和填充胸腔。它是内脏胸膜纤维化和增厚阻止肺再扩张的结果。我们报告一位62岁的女性,既往有慢性肾脏疾病和心力衰竭病史,射血分数保存,表现为双侧胸腔积液。右侧的积液被抽干。次日胸片示右肺底气胸,其边缘与积液边缘重合。第二天,她在同一部位出现了积液性气胸。在失代偿性心力衰竭的情况下,慢性胸腔积液是一种罕见但尚未报道的肺陷的原因。
{"title":"A Rare Case of Trapped Lung Cause by Chronic Pleural Effusion: Another Etiology of This Uncommon Disease","authors":"Hardik A. Fichadiya","doi":"10.19080/ijoprs.2022.05.555668","DOIUrl":"https://doi.org/10.19080/ijoprs.2022.05.555668","url":null,"abstract":"Trapped lung is defined by the inability of the lung to expand and fill the thoracic cavity. It is an outcome of fibrosis and thickening of visceral pleural preventing lung re-expansion. We present a 62 -year-old women with past medical history of chronic kidney disease and heart failure with preserved ejection fraction who presented with bilateral pleural effusions. Effusion on the right side was tapped draining a transudative fluid. Chest X ray on the following day showed a pneumothorax at the right lung base, the margins of which coincided which that of the effusion. The following day she now developed a hydro-pneumothorax in the same location. One rare yet reported cause of trapped lung is chronic pleural effusions in the setting of decompensated heart failure.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133047179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Lung Disease in Young IV Drug Abuser: A Case Report 青少年静脉吸毒致大疱性肺病1例报告
Pub Date : 2021-12-15 DOI: 10.19080/ijoprs.2021.05.555667
Amanpreet Kaur
Drug abuse is defined as the non-medical “recreational” use of drugs that may result in physical or psychological dependence. Complications resulting from intravenous drug abuse affect the lung more frequently than any other organ. Drug abusers are also at risk from a wide range of pulmonary complications not directly related to infection. Non-infectious disorders may mimic more common pulmonary disease and may lead to respiratory insufficiency. Reports have documented evidence of emphysema with or without bullae formation in users of intravenous drugs. Most cases have been in drug abusers who inject medications intended for oral use and have occurred in association with intravenous talcosis. Bullous degeneration has been reported in intravenous opiate abuse presenting with pneumothorax or localized chest pain possibly due to air trapping. We encountered a unique case of bilateral upper lobe bullae in a young intravenous heroin abuser presented to us with right-sided hydropneumothorax.
药物滥用被定义为可能导致身体或心理依赖的非医疗"娱乐性"使用药物。静脉药物滥用引起的并发症对肺的影响比其他任何器官都要大。药物滥用者还面临与感染没有直接关系的各种肺部并发症的风险。非传染性疾病可能模仿更常见的肺部疾病,并可能导致呼吸功能不全。报告有文献证据表明,静脉注射药物使用者的肺气肿伴或不伴大泡形成。大多数病例发生在注射口服药物的药物滥用者中,并与静脉滑石中毒有关。静脉阿片类药物滥用有大泡变性的报道,表现为气胸或局部胸痛,可能是由于空气困住。我们遇到了一个独特的病例双侧上叶大泡在一个年轻的静脉海洛因滥用者提出了右侧气胸积液。
{"title":"Bullous Lung Disease in Young IV Drug Abuser: A Case Report","authors":"Amanpreet Kaur","doi":"10.19080/ijoprs.2021.05.555667","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555667","url":null,"abstract":"Drug abuse is defined as the non-medical “recreational” use of drugs that may result in physical or psychological dependence. Complications resulting from intravenous drug abuse affect the lung more frequently than any other organ. Drug abusers are also at risk from a wide range of pulmonary complications not directly related to infection. Non-infectious disorders may mimic more common pulmonary disease and may lead to respiratory insufficiency. Reports have documented evidence of emphysema with or without bullae formation in users of intravenous drugs. Most cases have been in drug abusers who inject medications intended for oral use and have occurred in association with intravenous talcosis. Bullous degeneration has been reported in intravenous opiate abuse presenting with pneumothorax or localized chest pain possibly due to air trapping. We encountered a unique case of bilateral upper lobe bullae in a young intravenous heroin abuser presented to us with right-sided hydropneumothorax.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130184452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Specific Inhalation Challenge Test Results in Occupational and Non- Occupational Asthma Patients: Is Monitoring Peak Expiratory Flow Rate Sufficient for Diagnosis? 职业性和非职业性哮喘患者特异性吸入激发试验结果的比较:监测呼气峰流量是否足以诊断?
Pub Date : 2021-11-19 DOI: 10.19080/ijoprs.2021.05.555666
Cebrail Şimşek, Bilge Akgunduz, Gulden Sari
Objective: It is recommended to monitoring PEFR to diagnosing OA. Gold standard method is SIC test. The aim of this study is to evaluate comparison of SIC test results in patients with OA and non-OA and to discuss PEFR monitoring and underdiagnosed. Materials and Methods: 24 patients (16 OA, 8 non-OA) who underwent SIC test were analyzed retrospectively. Results: Although number of patients exposed to LMW (wood powders [n: 5]) was higher, IgE level was found significantly higher at OA (697.39 ± 839.36 kU/ml) (p: 0.027). Average PEFR monitoring days mean was 26.53±12.90.13 patients who diagnosed with OA with SIC was evaluated PEFR monitoring results were negative [%92.86]. Minimum FEV1 value on exposure day was lower in OA (p:0.001). Conclusion: We detected underdiagnosed cases rates were higher with diagnosing OA with PEFR monitoring alone. Our study also demonstrated that LMW agents cause immunological OA, independently from agent type and duration of exposure.
目的:建议监测PEFR对OA进行诊断。金标准方法是SIC试验。本研究的目的是评估骨性关节炎和非骨性关节炎患者SIC检测结果的比较,并讨论PEFR监测和漏诊。材料与方法:对24例骨性关节炎患者(16例OA, 8例非OA)进行回顾性分析。结果:虽然暴露于LMW(木粉[n: 5])的患者人数较多,但OA组的IgE水平明显升高(697.39±839.36 kU/ml) (p: 0.027)。诊断为OA合并SIC的患者平均PEFR监测天数为26.53±12.90.13天,PEFR监测结果为阴性[%92.86]。暴露日最小FEV1值在OA组较低(p:0.001)。结论:单独使用PEFR监测诊断OA,漏诊率较高。我们的研究还表明,LMW病原体引起免疫性OA,与病原体类型和暴露时间无关。
{"title":"Comparison of Specific Inhalation Challenge Test Results in Occupational and Non- Occupational Asthma Patients: Is Monitoring Peak Expiratory Flow Rate Sufficient for Diagnosis?","authors":"Cebrail Şimşek, Bilge Akgunduz, Gulden Sari","doi":"10.19080/ijoprs.2021.05.555666","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555666","url":null,"abstract":"Objective: It is recommended to monitoring PEFR to diagnosing OA. Gold standard method is SIC test. The aim of this study is to evaluate comparison of SIC test results in patients with OA and non-OA and to discuss PEFR monitoring and underdiagnosed. Materials and Methods: 24 patients (16 OA, 8 non-OA) who underwent SIC test were analyzed retrospectively. Results: Although number of patients exposed to LMW (wood powders [n: 5]) was higher, IgE level was found significantly higher at OA (697.39 ± 839.36 kU/ml) (p: 0.027). Average PEFR monitoring days mean was 26.53±12.90.13 patients who diagnosed with OA with SIC was evaluated PEFR monitoring results were negative [%92.86]. Minimum FEV1 value on exposure day was lower in OA (p:0.001). Conclusion: We detected underdiagnosed cases rates were higher with diagnosing OA with PEFR monitoring alone. Our study also demonstrated that LMW agents cause immunological OA, independently from agent type and duration of exposure.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"294 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121376034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of TSPO Ligand, Ro5-4864, on Lung Injury in ARDS Model Induced by ANTU in Rats TSPO配体Ro5-4864对ANTU所致ARDS模型大鼠肺损伤的影响
Pub Date : 2021-10-28 DOI: 10.19080/ijoprs.2021.05.555665
Emine Yilmaz-Can
{"title":"Effect of TSPO Ligand, Ro5-4864, on Lung Injury in ARDS Model Induced by ANTU in Rats","authors":"Emine Yilmaz-Can","doi":"10.19080/ijoprs.2021.05.555665","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555665","url":null,"abstract":"","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124889248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Activated Macrophage and Granulomatous Inflammation 活化巨噬细胞与肉芽肿性炎症
Pub Date : 2021-10-23 DOI: 10.19080/ijoprs.2021.05.555664
Mehwish Azhar
The granulomatous inflammation is a characteristic type of chronic inflammation in which main cells are macrophages, multinucleated cells and epithelioid cells. The dynamic structure of granuloma helps to defend the body from microbiological threats. Granulomatous inflammation is a histologic pattern of tissue reactions which appears following cell damage. A variety of systemic diseases are occurred by this special inflammatory response. The granulomatous inflammatory response is common in many infective, allergic, autoimmune, toxic and neoplastic diseases. Mechanism that regulates granulomatous inflammation is remain not properly understood. The pulmonary system is one of the most common concerned sites to face the granulomatous inflammation. Unlike the lungs, skin can be affected by different ways including direct inoculation, endogenous origins and hematogenous spread. In this theory, we discuss about formation of granuloma, and that the granulomatous inflammation is a protective mechanism of our body but sometimes it can also cause serious and severe diseases in different body organs.
肉芽肿性炎症是一种特征性的慢性炎症,其主要细胞为巨噬细胞、多核细胞和上皮样细胞。肉芽肿的动态结构有助于保护身体免受微生物的威胁。肉芽肿性炎症是细胞损伤后出现的组织反应的组织学模式。这种特殊的炎症反应可引起多种全身性疾病。肉芽肿性炎症反应在许多感染性、过敏性、自身免疫性、毒性和肿瘤疾病中都很常见。调节肉芽肿性炎症的机制尚不清楚。肺系统是肉芽肿性炎症最常见的关注部位之一。与肺不同,皮肤可以通过不同的方式受到影响,包括直接接种、内源性起源和血液传播。在这个理论中,我们讨论了肉芽肿的形成,肉芽肿性炎症是我们身体的一种保护机制,但有时也会引起身体不同器官的严重疾病。
{"title":"Activated Macrophage and Granulomatous Inflammation","authors":"Mehwish Azhar","doi":"10.19080/ijoprs.2021.05.555664","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555664","url":null,"abstract":"The granulomatous inflammation is a characteristic type of chronic inflammation in which main cells are macrophages, multinucleated cells and epithelioid cells. The dynamic structure of granuloma helps to defend the body from microbiological threats. Granulomatous inflammation is a histologic pattern of tissue reactions which appears following cell damage. A variety of systemic diseases are occurred by this special inflammatory response. The granulomatous inflammatory response is common in many infective, allergic, autoimmune, toxic and neoplastic diseases. Mechanism that regulates granulomatous inflammation is remain not properly understood. The pulmonary system is one of the most common concerned sites to face the granulomatous inflammation. Unlike the lungs, skin can be affected by different ways including direct inoculation, endogenous origins and hematogenous spread. In this theory, we discuss about formation of granuloma, and that the granulomatous inflammation is a protective mechanism of our body but sometimes it can also cause serious and severe diseases in different body organs.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134522978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Biologic Drugs for Treatment of Allergic Bronchopulmonary Aspergillosis 生物药物治疗过敏性支气管肺曲菌病的应用
Pub Date : 2021-10-11 DOI: 10.19080/ijoprs.2021.05.555663
S. Albogami
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic fungal infection that induces immunoglobulin E (IgE) production and eosinophils proliferation and affect mostly asthmatic and cystic fibrosis patients. The mainstay treatment for ABPA is systemic steroid and antifungal treatment which have increasing rates of treatment failure and side effects. Because of their mechanism of action in suppressing IgE or eosinophils, biologic drugs were expected to play an important role in the treatment of ABPA, however, their use in this issue was off label and lack the evidence. In this comprehensive and comparative review, 59 full text articles (228 patients) were selected. The outcomes were analyzed and the percentages of posttreatment change for each variable in each study were collected then the overall median percentages were calculated for each variable for each biologic drug. Comparative discussion of these outcomes was done in terms of clinical and functional response, reduction of exacerbation events, reduction of IgE level and eosinophils count, prevention of complications and patient’s ability to reduce steroid dose or discontinue it. The review shows that the use of biologic drugs for treatment of ABPA is associated with a significant clinical and functional improvement and reduction of exacerbation rates up to 90%. There is more reduction in post-treatment IgE level with mepolizumab and marked reduction in posttreatment eosinophils count with benralizumab. Mepolizumab has the better steroid-sparing effect. Changing from one biologic drug to another with different target in case of treatment failure is advisable. More stronger studies and randomized control trials are needed to figure out the use of biologic drugs for ABPA treatment.
过敏性支气管肺曲霉病(ABPA)是一种过敏性真菌感染,可诱导免疫球蛋白E (IgE)的产生和嗜酸性粒细胞的增殖,主要影响哮喘和囊性纤维化患者。ABPA的主要治疗是全身类固醇和抗真菌治疗,但治疗失败率和副作用增加。由于其抑制IgE或嗜酸性粒细胞的作用机制,生物药物有望在ABPA的治疗中发挥重要作用,然而,它们在这一问题上的使用是标签外的,缺乏证据。在这项综合比较综述中,选择了59篇全文文章(228例患者)。对结果进行分析,收集每项研究中每个变量的治疗后变化百分比,然后计算每种生物药物中每个变量的总体中位数百分比。从临床和功能反应、减少加重事件、降低IgE水平和嗜酸性粒细胞计数、预防并发症和患者减少类固醇剂量或停药的能力等方面对这些结果进行了比较讨论。该综述显示,使用生物药物治疗ABPA与显著的临床和功能改善以及恶化率降低高达90%相关。mepolizumab治疗后IgE水平降低更多,benralizumab治疗后嗜酸性粒细胞计数显著降低。Mepolizumab具有更好的类固醇节约效果。如果治疗失败,建议从一种生物药物改为另一种具有不同靶点的生物药物。需要更多更有力的研究和随机对照试验来确定使用生物药物治疗ABPA。
{"title":"Use of Biologic Drugs for Treatment of Allergic Bronchopulmonary Aspergillosis","authors":"S. Albogami","doi":"10.19080/ijoprs.2021.05.555663","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555663","url":null,"abstract":"Allergic bronchopulmonary aspergillosis (ABPA) is an allergic fungal infection that induces immunoglobulin E (IgE) production and eosinophils proliferation and affect mostly asthmatic and cystic fibrosis patients. The mainstay treatment for ABPA is systemic steroid and antifungal treatment which have increasing rates of treatment failure and side effects. Because of their mechanism of action in suppressing IgE or eosinophils, biologic drugs were expected to play an important role in the treatment of ABPA, however, their use in this issue was off label and lack the evidence. In this comprehensive and comparative review, 59 full text articles (228 patients) were selected. The outcomes were analyzed and the percentages of posttreatment change for each variable in each study were collected then the overall median percentages were calculated for each variable for each biologic drug. Comparative discussion of these outcomes was done in terms of clinical and functional response, reduction of exacerbation events, reduction of IgE level and eosinophils count, prevention of complications and patient’s ability to reduce steroid dose or discontinue it. The review shows that the use of biologic drugs for treatment of ABPA is associated with a significant clinical and functional improvement and reduction of exacerbation rates up to 90%. There is more reduction in post-treatment IgE level with mepolizumab and marked reduction in posttreatment eosinophils count with benralizumab. Mepolizumab has the better steroid-sparing effect. Changing from one biologic drug to another with different target in case of treatment failure is advisable. More stronger studies and randomized control trials are needed to figure out the use of biologic drugs for ABPA treatment.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132924302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Effects of Cannabinoid System on Acute Lung Injury Induced by Mesenteric Ischemia/Reperfusion in Rats 大麻素系统对大鼠肠系膜缺血再灌注急性肺损伤的影响
Pub Date : 2021-09-30 DOI: 10.19080/ijoprs.2021.05.555662
Emine Yilmaz-Can
{"title":"The Effects of Cannabinoid System on Acute Lung Injury Induced by Mesenteric Ischemia/Reperfusion in Rats","authors":"Emine Yilmaz-Can","doi":"10.19080/ijoprs.2021.05.555662","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555662","url":null,"abstract":"","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127480549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avoiding Aortic Injury During Thoracentesis: A Case Report with An Emphasis on Ultrasound Guidance 胸穿刺时避免主动脉损伤:以超声引导为主的一例报告
Pub Date : 2021-09-23 DOI: 10.19080/ijoprs.2021.05.555661
Sultan R. Alharbi
Percutaneous pigtail catheter thoracentesis is a common and relatively safe procedure for pleural drainage, often performed with ultrasound guidance. While injury to an intrathoracic organ is a rare and sometimes fatal complication of this procedure, ultrasound is an excellent tool for avoiding this complication and for evaluating pleural effusion. In this case report, the use of ultrasound imaging with various techniques and planes prior to and during thoracentesis is described for the identification of the thoracic aorta and for avoidance of fatal aortic injury.
经皮猪尾导管胸腔穿刺是一种常见且相对安全的胸膜引流方法,通常在超声引导下进行。虽然胸内器官损伤是该手术中一种罕见且有时致命的并发症,但超声是避免这种并发症和评估胸腔积液的极好工具。在本病例报告中,我们描述了在胸腔穿刺之前和期间使用各种技术和平面的超声成像来识别胸主动脉并避免致命的主动脉损伤。
{"title":"Avoiding Aortic Injury During Thoracentesis: A Case Report with An Emphasis on Ultrasound Guidance","authors":"Sultan R. Alharbi","doi":"10.19080/ijoprs.2021.05.555661","DOIUrl":"https://doi.org/10.19080/ijoprs.2021.05.555661","url":null,"abstract":"Percutaneous pigtail catheter thoracentesis is a common and relatively safe procedure for pleural drainage, often performed with ultrasound guidance. While injury to an intrathoracic organ is a rare and sometimes fatal complication of this procedure, ultrasound is an excellent tool for avoiding this complication and for evaluating pleural effusion. In this case report, the use of ultrasound imaging with various techniques and planes prior to and during thoracentesis is described for the identification of the thoracic aorta and for avoidance of fatal aortic injury.","PeriodicalId":257243,"journal":{"name":"International Journal of Pulmonary & Respiratory Sciences","volume":"8 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120999757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Pulmonary & Respiratory Sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1