mNP热疗过程中的热产生-应用于深部肿瘤

A. Lomia, L. Shoshiashvili, D. Kakulia, B. Baratashvili, G. Chaganava, G. Ghvedashvili, F. Shubitidze
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引用次数: 1

摘要

近年来,纳米粒子(NP)热疗成为细胞水平上治疗癌症最有前途的技术之一。研究表明,癌细胞比正常细胞更容易接受和积累NP[1]。我们在[1]中已经表明,Dartmouth mNP的产热机制不可能是迟滞。在本文中,我们提出了达特茅斯mNP的实验SAR测量,并给出了考虑粘性摩擦损失作为SAR产生主要机制的模拟结果。我们不仅在人体模型中模拟了涡流热的产生,也在人体模型中模拟了涡流热的产生。结果表明,涡流热效应的量级与mNP相同,显示了涡流最小化机制的必要性。
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Heat Production During mNP Hyperthermia - applied on a Deep Seated Tumors
Recently, nano-particles (NP) hyperthermia emerged as one of the most promising technologies for the treatment of cancers at the cell level. Studies show that cancer cells accept and accumulate NP more preferable than normal cells [1]. We have shown in [1], that heat production mechanism for Dartmouth mNP cannot be hysteresis. In this paper, we present experimental SAR measurement for Dartmouth mNP and give simulation results taking in account viscous friction loss as the main mechanism of SAR production. We have modeled eddy current heat generation in phantom as well as in the realistic human model. Results show that the eddy current heat effect is the same order as in mNP, which exhibits necessity of mechanism for eddy currents minimization.
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