布鲁诺舒尔茨1930年的文章“老年偏执型精神病的遗传关系”。

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Pub Date : 2023-11-15 DOI:10.1002/ajmg.b.32965
Kenneth S. Kendler, Astrid Klee
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引用次数: 0

摘要

Kraepelin在1899年出版的第6版教科书中提出了“老年偏执型精神病”的诊断类别。在这篇1930年的文章中,Bruno Schulz研究了51名“老年偏执型精神病”先证患者的父母、兄弟姐妹、后代和侄女/侄子的几种疾病和特征的病态风险(MR)。他的结果允许对Kraepelin的老年偏执型精神病分类的有效性进行评估,特别是,它是一种由“老年性变化”引起的精神病还是迟发性精神分裂症。在这四组亲属中,精神分裂症的MR从0到2.4%不等,4人中有3人略高于总体预期,但远低于精神分裂症亲属的平行结果。相比之下,这些亲属的怪癖率一致高于人口比率,有时接近精神分裂症亲属的怪癖率。舒尔茨从他的研究中得出结论,老年偏执型精神病是一种与精神分裂症没有密切关系的独特疾病。然而,他建议家族史和/或病态前的古怪特征会增加老年时患偏执型精神病的风险,特别是当与身体或智力衰退相关时。他不确定他在这项研究中发现的怪癖特征与在精神分裂症患者亲属中观察到的怪癖特征是非常相似还是不同。据我们所知,这项研究是第一次明确使用家庭研究设计来解决一个病理性问题——在这个案例中,老年偏执型精神病和精神分裂症之间的家族关系。
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Bruno Schulz's 1930 article “The Hereditary Relationships of Old-Age Paranoid Psychosis”

In the 1899 6th edition of his influential textbook, Kraepelin proposed a diagnostic category of “Old-Age Paranoid Psychosis.” In this 1930 article, Bruno Schulz studied the morbid risk (MR) of several disorders and traits in the parents, siblings, offspring, and nieces/nephews of 51 probands with “Old-Age Paranoid Psychosis.” His results permitted an evaluation of the validity of Kraepelin's category of Old-Age Paranoid Psychosis, in particular, whether it was a form of psychosis resulting from “senile changes” or late-onset schizophrenia. The MR of schizophrenia in these four groups of relatives varied from 0 to 2.4% with 3 of 4 somewhat higher than population expectations but much lower than parallel results in relatives of schizophrenics. By contrast, the rates of eccentricity in these relatives were uniformly elevated over population rates, sometimes approaching those seen in relatives of schizophrenics. Schulz concluded, from his study, that Old-Age Paranoid Psychosis was a distinct disorder not closely related to schizophrenia. However, he suggested that a family history and/or a premorbid trait of eccentricity increases the risk of developing a paranoid psychosis in old age, particularly when associated with physical or mental decline. He was uncertain about whether the trait of eccentricity he found in this study was very similar or distinct from that observed in excess in relatives of schizophrenics. This study was the first, to the best of our knowledge, to use a family study design explicitly to address a nosologic question—in this case the familial relationship between Old-Age Paranoid Psychosis and schizophrenia.

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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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