以α- d -葡萄糖醛酸和α- d -半乳糖醛酸为支架的二硫代磷酸阿托品和二硫代膦酸盐

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Chemical Sciences Pub Date : 2023-11-02 DOI:10.1007/s12039-023-02224-8

Ilyas S Nizamov, Georgiy G Shumatbaev, Ilnar D Nizamov, Varis R Urazbakhtin, Marina P Shulaeva, Oscar K Pozdeev, Elvira S Batyeva

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引用次数: 0

摘要

具有光学活性的二硫代磷酸和二硫代膦酸，含葡萄糖醛酸和半乳糖醛酸二丙酮取代基，与外消旋阿托品反应得到二硫代磷酸阿托品或二硫代膦酸酯作为非对映体的混合物。二硫代磷酸和二硫代膦酸及其阿托品盐具有抗菌活性。摘要:含α- d -葡萄糖醛酸和α- d -半乳糖醛酸取代基的光活性二硫代磷酸和二硫代膦酸与外消旋阿托品反应得到二硫代磷酸阿托品或二硫代膦酸酯作为非对映体的混合物。二硫代磷酸和二硫代膦酸及其阿托品盐具有抗菌活性。

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Atropinium dithiophosphates and dithiophosphonates on the basis of α-D-glucofuranose and α-D-galactopyranose diacetonide scaffolds

Optically active dithiophosphoric and dithiophosphonic acids bearing glucofuranose and galactopyranose diacetonide substituents reacted with racemic atropine to give atropinium dithiophosphates or dithiophosphonates as the mixture of diastereomers. Dithiophosphoric and dithiophosphonic acids and their atropinium salts possess antimicrobial activity.

Graphical abstract

SYNOPSIS: Optically active dithiophosphoric and dithiophosphonic acids bearing α-D-glucofuranose and α-D-galactopyranose diacetonide substituents reacted with racemic atropine to give atropinium dithiophosphates or dithiophosphonates as the mixture of diastereomers. Dithiophosphoric and dithiophosphonic acids and their atropinium salts possess antimicrobial activity.

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.