帕博西尼和氟维司汀联合治疗的患者的药物性间质性肺病

Maria Angela Vittoria Licata, Lucia Maria Porro, Giacomo Sgalla, Luca Richeldi
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引用次数: 0

摘要

一名59岁无肺部疾病史的患者在接受氟维司汀和帕博西尼治疗转移性乳腺癌后出现咯血和急性呼吸衰竭发作。高分辨率胸部CT示弥漫性磨玻璃影,小叶间隔和支气管血管周围间质弥漫性平滑增厚,与药物性间质性肺病(DIILD)一致。几天的高剂量类固醇治疗将患者的气体交换从PaO2/FiO2的75提高到200。出院后,肿瘤科医生恢复氟维司汀治疗,在随后的随访中没有发生额外的不良事件。
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Drug-Induced Interstitial Lung Disease in a patient treated with a combination of palbociclib and fulvestrant
A 59-year-old patient without a history of pulmonary disease presented with episodes of hemoptysis and acute respiratory failure after receiving fulvestrant and palbociclib for metastatic breast cancer. The High-Resolution chest CT demonstrated diffuse ground glass opacities, as well as diffuse smooth thickening of the interlobular septa and peribronchovascular interstitium, which are consistent with Drug-Induced Interstitial Lung Disease (DIILD). A few days of high-dose steroid therapy improved the patient's gas exchange from PaO2/FiO2 of 75 to 200. After hospital discharge, the oncologist resumed fulvestrant therapy, with no additional adverse events occurring during the subsequent follow-up.
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