分泌性猫传染性腹膜炎猫回肠中FIPV3-70抗原表达的免疫组化研究

IF 0.7 4区 农林科学 Q3 VETERINARY SCIENCES Acta Veterinaria-Beograd Pub Date : 2023-09-01 DOI:10.2478/acve-2023-0032
Todor Novakov, Ivica Gjurovski, Spiro Bozinoski, Aleksandar Janevski, Elena Atanaskova Petrov, Slavica Kostadinova Kunovska, Trpe Ristoski
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引用次数: 0

摘要

猫感染性腹膜炎(FIP)是猫死亡最常见的感染性原因之一,同时伴有泛白细胞减少症和病毒性上呼吸道感染。FIP更容易影响免疫系统较弱或受到抑制的猫。据认为,巨噬细胞和单核细胞的感染在致病过程中起主要作用。为了对这种传染病做出明确的诊断,需要对组织进行组织病理学检查,并通过免疫组织化学(IHC)检测猫冠状病毒(FCoV)。在这项研究中,15只年龄在5至24个月之间,临床怀疑患有FIP的猫进行了尸检、病理组织学和免疫组织化学检查。结果显示,所有猫腹腔积液伴脓肉芽肿遍布腹腔浆膜。免疫组化法15只猫中有10只呈FIP阳性。该方法还显示了抗原在巨噬细胞中的沉积,从而证实了它们在FIP发病机制中的作用。
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Immunohistochemical investigation of FIPV3-70 antigen expression in the ileum of cats with effusive feline infective peritonitis
Abstract One of the most common infectious causes of cat mortality is feline infective peritonitis (FIP), along with panleukopenia and viral upper respiratory tract infections. FIP is more likely to affect cats whose immune system is weak or suppressed. It is thought that the infection of macrophages and monocytes plays a major role in the pathogenic process. In order to set a definitive diagnosis for this infectious disease, a histopathological examination of tissues, and feline coronavirus (FCoV) detection by immunohistochemistry (IHC) is necessary. In this investigation, 15 cats between the ages of 5 and 24 months with clinical suspicion of FIP, underwent post-mortem necropsy, pathohistological and immunohistochemical examination. The results showed that all the cats had abdominal effusion with pyogranulomas throughout the abdominal serosa. Ten out of fifteen cats were FIP positive using immunohistochemical methods. This method also showed the antigen deposition in the macrophages thus confirming their role in the pathogenesis of FIP.
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来源期刊
Acta Veterinaria-Beograd
Acta Veterinaria-Beograd 农林科学-兽医学
CiteScore
1.30
自引率
16.70%
发文量
33
审稿时长
18-36 weeks
期刊介绍: The Acta Veterinaria is an open access, peer-reviewed scientific journal of the Faculty of Veterinary Medicine, University of Belgrade, Serbia, dedicated to the publication of original research articles, invited review articles, and to limited extent methodology articles and case reports. The journal considers articles on all aspects of veterinary science and medicine, including the diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
期刊最新文献
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