Dominique Bataille, Susan L. Chan, Philippe Delagrange, Daniel J. Drucker, Burkhard Göke, Rebecca Hills, Kelly E. Mayo, Laurence J. Miller, Roberto Salvatori, Bernard Thorens
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引用次数: 0
摘要
胰高血糖素受体家族(由NC-IUPHAR胰高血糖素受体家族小组委员会商定的命名[165])由内源性肽(27-44 aa)激素胰高血糖素、胰高血糖素样肽1、胰高血糖素样肽2、葡萄糖依赖性胰岛素性多肽(也称为胃抑制多肽)、GHRH和分泌素激活。一种常见的前体(GCG)产生胰高血糖素、胰高血糖素样肽1和胰高血糖素样肽2肽[121]。关于GLP-1和GLP-1R的结构、它们相互作用的分子基础以及相关信号事件的最新综述见de Graaf et al.， 2016[90]。
The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [165]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [121]. For a recent review on the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the associated signaling events see de Graaf et al., 2016 [90].
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