GtoPdb v.2023.1中钙和钠活化的钾通道(KCa， KNa

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f69/2023.1

Richard Aldrich, K. George Chandy, Stephan Grissmer, George A. Gutman, Leonard K. Kaczmarek, Aguan D. Wei, Heike Wulff

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引用次数: 5

摘要

钙和钠活化钾通道是钾通道6TM家族的成员，该家族包括电压门控KV亚家族，包括KCNQ亚家族、EAG亚家族(包括hERG通道)、Ca2+活化的Slo亚家族(实际上有6或7TM)和Ca2+和Na+活化的SK亚家族(命名由NC-IUPHAR钙和钠活化钾通道小组委员会同意[126])。对于2TM家族，成孔亚基形成四聚体，并且可以在亚族内形成异质通道(例如KV1.1与KV1.2;KCNQ2和KCNQ3)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1

Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [126]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

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