磷酸二酯酶，GtoPdb v.2023.1中的3'，5'-环核苷酸(PDEs)

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f260/2023.1

Chen Yan

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摘要

3'，5'-环核苷酸磷酸二酯酶(PDEs, 3'，5'-环核苷酸5'-核苷酸水解酶)，E.C. 3.1.4.17，催化3'，5'-环核苷酸(通常是环AMP或环GMP)的水解。异丁基甲基黄嘌呤是一种非选择性抑制剂，除PDE 8A、8B和9A外，其IC50值在毫摩尔范围内。2'，3'-环核苷酸3'-磷酸二酯酶(E.C. 3.1.4.37 CNPase)活性与中枢神经系统发育过程中的髓磷脂形成有关。

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Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) in GtoPdb v.2023.1

3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

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IUPHAR/BPS Guide to Pharmacology CITE

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