GtoPdb v.2023.1中向内整流钾通道(KIR

IUPHAR/BPS Guide to Pharmacology CITE Pub Date : 2023-04-26 DOI:10.2218/gtopdb/f74/2023.1

John P. Adelman, David E. Clapham, Hiroshi Hibino, Atsushi Inanobe, Lily Y. Jan, Andreas Karschin, Yoshihiro Kubo, Yoshihisa Kurachi, Michel Lazdunski, Takashi Miki, Colin G. Nichols, Lawrence G. Palmer, Wade L. Pearson, Henry Sackin, Susumu Seino, Paul A. Slesinger, Stephen Tucker, Carol A. Vandenberg

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引用次数: 0

摘要

K通道的2TM畴族也被称为内整流K通道族。该家族包括组成活性的强内向整流K通道(Kir2.x)， g蛋白激活的内向整流K通道(Kir3.x)和atp敏感的K通道(Kir6. x)。x，与磺酰脲受体(SUR1-3)结合)。形成孔隙的α亚基形成四聚体，并且可以在亚族中形成异质通道(例如Kir3.2和Kir3.3)。

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Inwardly rectifying potassium channels (KIR) in GtoPdb v.2023.1

The 2TM domain family of K channels are also known as the inward-rectifier K channel family. This family includes the strong inward-rectifier K channels (Kir2.x) that are constitutively active, the G-protein-activated inward-rectifier K channels (Kir3.x) and the ATP-sensitive K channels (Kir6.x, which combine with sulphonylurea receptors (SUR1-3)). The pore-forming α subunits form tetramers, and heteromeric channels may be formed within subfamilies (e.g. Kir3.2 with Kir3.3).

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