褪黑素与姜黄素对胺碘酮治疗的成年雄性白化大鼠肺保护作用的比较研究

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2737
Nehal E. Refaay, Noha M. Halloull, Nehal A. Amer
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引用次数: 0

摘要

胺碘酮(AMR)是一种非常有效的抗心律失常药物,在预防和治疗室性和室上性心律失常方面优于其他治疗方法。褪黑素由多种器官产生,包括松果体。它具有抗氧化和抗炎的特性。姜黄素提供多种不同的健康益处,并已被证明具有相当大的抗氧化作用。本研究的目的是探讨和评估褪黑素和姜黄素对amr引起的肺损伤的预防作用。60成年男性白化病老鼠用于这项研究同样分为5组:主要(控制没有药物,虚假的分成两个子组sham1接收500 ug / kg体重(BW)褪黑素和姜黄素sham2接受200毫克/公斤体重,AMR治疗组接受40毫克/公斤BW的AMR口头,AMR与褪黑素组receiving500Ug /公斤体重(BW)褪黑激素and40毫克/公斤BW AMR, AMR和姜黄素组接受200毫克/公斤体重的AMR的姜黄素和40毫克/公斤体重)。研究持续6周。实验结束时对肺组织进行组织病理学和生化评价,结果显示amr处理组炎症细胞因子(il6)和氧化参数显著升高,肺纤维化改变,细胞浸润明显。然而,褪黑素和姜黄素治疗改善了纤维化,通过减少TGF-β1阳性染色面积和CD68染色的巨噬细胞数量检测到,同时改善了组织的抗氧化状态。因此,褪黑素和姜黄素对amr诱导的纤维化具有保护作用。
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A Comparative Study of Lung-protective Effects of Melatonin Versus Curcumin in Amiodarone Treated Adult Male Albino rats
Amiodarone (AMR) is a very powerful and efficient anti-arrhythmic agent since it outperforms other treatments in preventing and treating ventricular and supraventricular dysrhythmias. Melatonin is produced by a variety of organs, including the pineal gland. It has anti-oxidant and anti-inflammatory properties. Curcumin provides a variety of different health benefits and has been demonstrated to have considerable antioxidant action. The purpose of this study was to look into and evaluate the preventive benefits of melatonin and curcumin against AMR-induced lung damage.60 adult male albino rats were utilized in this study divided equally into 5 main groups: (control with no drugs, sham divided into 2 subgroups sham1 receiving 500Ug/kg body weight (BW) of melatonin and sham2 receiving 200 mg/kg BW of curcumin, AMR treated group receiving 40 mg/kg BW of AMR orally, AMR with melatonin group receiving500Ug/kg body weight (BW) of melatonin and40 mg/kg BW of AMR, and AMR with curcumin group receiving 200 mg/kg BW of curcumin and 40 mg/kg BW of AMR). this study was continued for 6 weeks. The lung tissue was processed for histopathological and biochemical evaluation at the end of the experiment and revealed significant elevations in inflammatory cytokine (il6) and oxidative parameters, lung alterations with fibrosis and marked cellular infiltration in the AMR-treated group. Yet treatment with melatonin and curcumin improved fibrosis detected by decreased area of positive TGF-β1 staining and lower number of stained macrophages by CD68 along with improving the antioxidant status of the tissue. Thus melatonin and curcumin had a protective effect over AMR-induced fibrosis.
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来源期刊
Biomedical and Pharmacology Journal
Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
1.20
自引率
0.00%
发文量
189
期刊介绍: Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.
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