不同纳米形式氟康唑抗白色念珠菌活性的体外评价

Q3 Pharmacology, Toxicology and Pharmaceutics Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2720
Ahmed Luay Osman, Salah Eldin Omar Hussein, Iqra Nizam, Deepa Dilip, Mariam Mahamadou, Jood Al Herafi, Sana Gulroz, Ibrahim Elsayed, Abd Elgadir Elamin Eltom, Devapriya Finney, raveen Kumar Kandakurti
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引用次数: 0

摘要

目的:比较九种不同纳米颗粒含氟康唑变体与标准氟康唑在实验室环境下对白色念珠菌的抑菌效果。设计:本研究是一项基于实验室的实验研究。环境:本研究在阿吉曼海湾医科大学医学检验科学系进行。研究对象:本研究采用致病性白色念珠菌ATCC66027标准菌株进行实验。干预:白色念珠菌暴露于不同浓度的九种不同的纳米颗粒含氟康唑形式。将生物和药物的混合物孵育2分钟,然后将50µL转移到Sabouraud Dextrose琼脂板上。然后在37℃下孵育48小时。主要结果测量:主要结果测量是使用菌落计数器计数菌落,将cfu /mL数与不同纳米形式氟康唑的浓度绘制,以估计有效性差异。结果:与普通氟康唑相比,纳米氟康唑能有效抑制白色念珠菌的生长,特别是在较高浓度下。该研究强调,纳米制剂的小尺寸允许氟康唑更好地渗透,增强其对白色念珠菌的有效性。结论:该研究得出结论,与标准形式的氟康唑相比,含有纳米颗粒的氟康唑变体在减少白色念珠菌菌落计数方面表现出显著差异。
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An In Vitro Evaluation of Anti-fungal Activity of Different Nano forms of Fluconazole Against Candida albicans
Objective: The study aims to compare the antifungal effectiveness of nine different nano-particle- containing fluconazole variants with the standard form of fluconazole against Candida albicans in a laboratory setting. Design: The study is an experimental laboratory-based study. Setting: The research was conducted in the department of Medical Laboratory Sciences at Gulf Medical University, Ajman. Subjects: The study used standard strains of pathogenic Candida albicans ATCC66027 for experimentation. Intervention: Candida albicans was exposed to varying concentrations of nine different nano- particle-containing fluconazole forms. The mixture of the organism and drug was incubated for 2 minutes, followed by transferring 50 µL to Sabouraud Dextrose agar plates. These plates were then incubated at 37 °C for 48 hours. Main Outcome Measure: The primary outcome measure was the counting of colonies using a colony counter, with the number of CFUs/mL plotted against the concentration of different nano forms of fluconazole to estimate differences in effectiveness. Results: The findings suggest that the nano form of fluconazole effectively inhibits the growth of Candida albicans, especially at higher concentrations, compared to the normal form of fluconazole. The study highlights that the small size of the nano agents allows for better penetration of fluconazole, enhancing its effectiveness against Candida albicans. Conclusion: The study concludes that nano-particle-containing fluconazole variants demonstrate significant variations in reducing the colony count of Candida albicans when compared to the standard form of fluconazole.
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Biomedical and Pharmacology Journal
Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
1.20
自引率
0.00%
发文量
189
期刊介绍: Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.
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